Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 1 Characteristics of the study population

From: Costs and health-related quality of life in Alpha-1-Antitrypsin Deficient COPD patients

  Subgroups p-value
  A B B1 B2 A vs. B B1 vs. B2
N 2049 131 106 25   
 Age (years) 65.4 (8.2) 60.3 (10.0) 59.6 (9.9) 63.1 (10.2) <.001a .12a
  % Age < 45 years 1.0 3.8 3.8 4.0 <.001b .63 b
  % Age 45–55 years 9.1 29.0 30.19 24.0   
  % Age 56–65 years 33.6 29.8 31.1 24.0   
  % Age 66–75 years 44.1 31.3 30.2 36.0   
  % Age > 75 years 12.1 6.1 4.72 12.0   
 Gender
  % Males 61.1 56.5 62.3 32.0 .30b .01b
 COPD GOLD Grade      .01b <.001b
  % Grade 1 (FEV1% pred. ≥ 80%) 9.0 4.6 4.7 4.0   
  % Grade 2 (50 ≤ FEV1% pred. < 80) 42.3 34.4 24.5 76.0   
  % Grade 3 (30 ≤ FEV1% pred. < 50) 38.1 42.8 50.9 8.0   
  % Grade 4 (FEV1% pred. < 30) 10.5 18.3 19.8 12.0   
 Education      <.001b .86b
  % Basic school education 57.0 32.1 33.0 28.0   
  % Secondary school education 26.0 43.5 42.5 48.0   
  % Higher school education 17.0 24.4 24.5 24.0   
 Smoking status      <.001b .25b
  % Never smokers 5.4 23.7 20.8 36.0   
  % Former smokers 69.2 75.6 78.3 64.0   
  % Smokers 25.4 0.7 0.9 0.0   
 BMI (kg/m2) 26.8 (5.3) 24.7 (4.0) 24.6 (4.1) 24.8 (3.6) <.001a .85a
  % Normal weight (18.5 ≤ BMI < 25) 35.7 52.7 52.8 52.0 <.001b .64b
  % Overweight (25 ≤ BMI < 30) 37.1 33.6 32.1 40.0   
  % Obese (BMI ≥ 30) 23.7 9.9 10.4 8.0   
  % Underweight (BMI < 18.5) 3.5 3.8 4.7 0.0   
 Comorbidities       
  Count 3.9 (2.6) 3.1 (2.5) 3.0 (2.5) 3.4 (2.3) <.001c .30c
  % Liver cirrhosis 1.3 1.5 1.9 0.0 .68b .49b
  % Hepatitis 5.4 6.9 8.5 0.0 .48b .13b
  1. Data are mean (standard deviation) or percentage (%)
  2. A = COPD patients without Alpha-1-antitrypsin deficiency (AATD), B = COPD patients with AATD, B1 = COPD patients with AATD and augmentation therapy (AT), B2 = COPD patients with AATD but without AT
  3. a p-value based on t-test, b p-value based on Chi2-test, cWilcoxon signed rank test