Fig. 5

Distribution of compounds across EBC groups in Cohort 3. a Venn diagram depicting the overlap of metabolites in four categories based on subject from the untargeted metabolomics analysis. Metabolites were filtered for presence in at least two out of the four groups; b Hierarchical clustering of 172 metabolites present in at least two EBC groups. Blue sections indicate low metabolite abundances and red sections indicate high abundance levels. The healthy EBC subjects appear to have a majority of lower abundance metabolites compared to the other three groups; c Concentration levels of four eicosanoids detected in all four sample groups using targeted LC-MS. Samples were analyzed on a triple quadruple mass spectrometer