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Table 1 Cardiac hemodynamic and echocardiographic analyses of control and MCT-treated (over 2, 4, and 6 weeks) rats

From: Altered mTOR and Beclin-1 mediated autophagic activation during right ventricular remodeling in monocrotaline-induced pulmonary hypertension

Group

CON-2 W

(n = 8)

MCT-2 W

(n = 12)

CON-4 W

(n = 8)

MCT-4 W

(n = 10)

CON-6 W

(n = 8)

MCT-6 W

(n = 8)

RVSP (mmHg)

23.3 ± 1.8

30.1 ± 1.5*

23.9 ± 1.6

37.1 ± 2.7**※

24.7 ± 2.1

51.1 ± 3.7 **※※△

RVWT (mm)

0.911 ± 0.09

0.976 ± 0.15*

0.924 ± 0.11

1.18 ± 0.16**※

0.932 ± 0.12

1.45 ± 0.13**※※△

RVEDD (mm)

36.3 ± 1.2

36.9 ± 1.1

37.9 ± 1.4

51.4 ± 2.9*※※

38.7 ± 1.9

58.9 ± 2.7**※※△

BW (g)

355 ± 13

344 ± 16

398 ± 14

361 ± 21*※

469 ± 17

357± 27**※※△

RVEDD/BW (mm/kg)

11.8 ± 0.8

10.7 ± 0.9

11.1 ± 0.7

14.1 ± 1.0*※

10.9 ± 0.9

17.3 ± 1.3**※※△

HR (bpm)

375 ± 9

379 ± 8

383 ± 10

403 ± 8

374 ± 10

419 ± 13*

TAPSE (mm)

0.28 ± 0.013

0.29 ± 0.019

0.29 ± 0.014

0.24 ± 0.015*※

0.30 ± 0.021

0.15 ± 0.026**※※△

RVEF (%)

61.5 ± 3.1

59.01 ± 2.1

63.8 ± 2.1

49.5 ± 3.6*※

62.7 ± 2.9

35.5 ± 6.0**※※△

RV FAC (%)

55.1 ± 2.9%

54.1 ± 3.3%

54.1 ± 3.1%

43.5 ± 5.1%*※

56.1 ± 2.7%

27 ± 3.9%**※※△

PAAT (ms)

32.2 ± 0.10

29.2 ± 0.15*

32.1 ± 0.11

25.9 ± 0.17**※

31.4 ± 0.10

22.6 ± 0.19**※※△

  1. RVSP Right ventricular systolic pressure, RVWT Right ventricular wall thickness, RVEDD Right ventricular diastolic diameter, BW Body weight, HR Heart rate (beats per minute), TAPSE Tricuspid annular plane systolic excursion, RVEF Right ventricular ejection fraction, RV FAC Right ventricular fractional area change, PAAT pulmonary artery acceleration time
  2. Values are presented as mean ± standard deviation. * P < 0.05 and ** P < 0.01, versus age-matched rat; ※ P < 0.05, ※※ P < 0.01, versus MCT-2 W; â–³ P < 0.05, △△ P < 0.01, versus MCT-4 W