Table 5 Interaction of sCD14 and CD14 haplotypes with lung function
From: Interaction of CD14 haplotypes and soluble CD14 on pulmonary function in agricultural workers
Variable | FEV1Base model (n = 549) | FEV1Plus haplotypes (n = 545) | FEV1/FVC Base model (n = 549) | FEV1/FVC Plus haplotypes (n = 545) |
|---|---|---|---|---|
Age, yrs | -0.09 (0.10) | -0.09 (0.10) | -0.07 (0.04) | -0.08 (0.04) |
Body mass index, kg/m3 | -0.37 (0.12)* | -0.34 (0.12)* | 0.14 (0.05)* | 0.14 (0.05)* |
Sex | ||||
 Male | Referent | Referent | Referent | Referent |
 Female | 6.17 (5.11) | 6.79 (5.14) | 4.39 (2.17)* | 4.55 (2.18)* |
Education | ||||
 ≤ High School | Referent | Referent | Referent | Referent |
 > High School | 2.51 (1.61) | 2.68 (1.62) | 1.22 (0.68) | 1.12 (0.69) |
Race | ||||
 White | Referent | Referent | Referent | Referent |
 Other | 2.97 (3.89) | -2.52 (4.42) | 0.78 (1.65) | 0.23 (1.89) |
 Worked on Farm, yrs | 0.06 (0.04) | 0.06 (0.04) | 0.01 (0.02) | 0.01 (0.02) |
COPDSmoke | ||||
 No COPD, Never smokers | Referent | Referent | Referent | Referent |
 No COPD, Ever smokers | 0.01 (2.24) | -0.33 (2.25) | 0.74 (0.95) | -0.84 (0.96) |
 COPD | -22.03 (2.3)* | -22.03 (2.31)* | -17.13 (0.98)* | -17.12 (0.98)* |
sCD14 | ||||
 ≤ Median | Referent | Referent | Referent | Referent |
 > Median | -3.19 (1.57)* | 0.51 (3.10) | -1.22 (0.66)# | -1.66 (1.31) |
Haplotypes | ||||
 GCCA |  | Referent |  | Referent |
 ATCG | - | -0.52 (2.00) | - | -1.32 (0.83) |
 GTTG |  | 1.81 (1.89) |  | -0.02 (0.80) |
 GTCA |  | -2.80 (3.32) |  | -4.16 (1.40)* |
 Other |  | 12.53 (4.78)* |  | 1.73 (2.08) |
Interaction | ||||
 GCCA x ≤ Median sCD14 (n = 111) |  | Referent |  | Referent |
 ATCG x > Median sCD14 (n = 72) | - | -0.11 (2.83) | - | 1.39 (1.20) |
 GTTG x > Median sCD14 (n = 59) |  | -6.94 (2.85)* |  | -1.08 (1.21) |
 GTCA x > Median sCD14 (n = 24 |  | 0.05 (4.45) |  | 3.54 (1.89)# |
 Other x > Median sCD14 (n = 6) |  | -9.54 (6.46) |  | -3.78 (2.78) |