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Table 2 Sputum cytokine mRNA levels in control and asthmatic individuals

From: Cluster analysis of sputum cytokine-high profiles reveals diversity in T(h)2-high asthma patients

  Control (n = 80) Asthma (n = 205) P value Adjusted P value* “Cytokine-high” n=, (%) “Cytokine-low” n=, (%)
IFN-γ 0.12 – 0.27 – 1.20 0.07 – 0.30 – 1.26 0.35 0.42 22 (11%) 38 (19%)
IL-4 0.00 – 0.00 – 0.00 0.00 – 0.00 – 3.14 <0.0001 0.0006 81 (40%) 0
IL-5 0.16 – 1.41 – 6.89 0.15 – 1.36 – 10.3 0.49 0.49 30 (15%) 22 (11%)
IL-13 0.00 – 0.00 – 1.07 0.00 – 0.27 – 4.10 <0.0001 0.0006 56 (27%) 0
IL-10 0.42 – 0.96 – 2.34 0.44 – 1.20 – 3.52 0.018 0.04 41 (20%) 19 (9%)
IL-17A 0.27 – 1.73 – 9.49 0.21 – 1.62 – 12.55 0.26 0.35 26 (13%) 33 (16%)
IL-17 F 0.25 – 2.3 – 14.02 0.16 – 1.99 – 16.41 0.15 0.3 23 (11%) 34 (17%)
IL-22 0.00 – 0.17 – 1.60 0.00 – 0.14 – 2.06 0.49 0.49 29 (14%) 0
IL-25 0.34 – 2.37 – 15.28 0.19 – 2.18 – 17.78 <0.0001 0.0006 26 (13%) 34 (17%)
TNF 0.07 – 0.25 – 1.95 0.03 – 0.14 – 1.95 0.22 0.35 7 (3%) 49 (24%)
IL-6 0.00 – 0.05 – 0.19 0.00 – 0.03 – 0.17 0.0002 0.0006 16 (8%) 28 (14%)
IL-1β 0.24 – 0.50 – 1.15 0.08 – 0.48 – 1.68 0.25 0.35 35 (17%) 51 (25%)
  1. Sputum cytokine mRNA levels were represented as median and 10th–90th percentile value and analysis between both groups was performed by Mann-Whitney test. *P value after correction for multiple comparison (Benjamini-Hochberg correction)