Cluster analysis of sputum cytokine-high profiles reveals diversity in T(h)2-high asthma patients

Respiratory Research

Table 2 Sputum cytokine mRNA levels in control and asthmatic individuals

	Control (n = 80)	Asthma (n = 205)	P value	Adjusted P value*	“Cytokine-high” n=, (%)	“Cytokine-low” n=, (%)
IFN-γ	0.12 – 0.27 – 1.20	0.07 – 0.30 – 1.26	0.35	0.42	22 (11%)	38 (19%)
IL-4	0.00 – 0.00 – 0.00	0.00 – 0.00 – 3.14	<0.0001	0.0006	81 (40%)	0
IL-5	0.16 – 1.41 – 6.89	0.15 – 1.36 – 10.3	0.49	0.49	30 (15%)	22 (11%)
IL-13	0.00 – 0.00 – 1.07	0.00 – 0.27 – 4.10	<0.0001	0.0006	56 (27%)	0
IL-10	0.42 – 0.96 – 2.34	0.44 – 1.20 – 3.52	0.018	0.04	41 (20%)	19 (9%)
IL-17A	0.27 – 1.73 – 9.49	0.21 – 1.62 – 12.55	0.26	0.35	26 (13%)	33 (16%)
IL-17 F	0.25 – 2.3 – 14.02	0.16 – 1.99 – 16.41	0.15	0.3	23 (11%)	34 (17%)
IL-22	0.00 – 0.17 – 1.60	0.00 – 0.14 – 2.06	0.49	0.49	29 (14%)	0
IL-25	0.34 – 2.37 – 15.28	0.19 – 2.18 – 17.78	<0.0001	0.0006	26 (13%)	34 (17%)
TNF	0.07 – 0.25 – 1.95	0.03 – 0.14 – 1.95	0.22	0.35	7 (3%)	49 (24%)
IL-6	0.00 – 0.05 – 0.19	0.00 – 0.03 – 0.17	0.0002	0.0006	16 (8%)	28 (14%)
IL-1β	0.24 – 0.50 – 1.15	0.08 – 0.48 – 1.68	0.25	0.35	35 (17%)	51 (25%)

Sputum cytokine mRNA levels were represented as median and 10^th–90^th percentile value and analysis between both groups was performed by Mann-Whitney test. *P value after correction for multiple comparison (Benjamini-Hochberg correction)

ISSN: 1465-993X