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Table 1 Clinical Characteristics of the subjects in the study cohort

From: Dual polarization of human alveolar macrophages progressively increases with smoking and COPD severity

 

Severe COPD

Moderate COPD

Smokers w/o COPD

Non Smokers

Donors

Subjects examined (nM/nF)

9 M/2 F

11 M/1 F

13 M

6 M/5 F

4 M/2 F

Age, yrs

62 ± 9

66 ± 8

63 ± 8

62 ± 14

56 ± 6

Smoking history, pk-yrs

46 ± 28

50 ± 19

44 ± 23

-

-

FEV1, % pred

33 ± 9 †‡

68 ± 9‡

100 ± 10

106 ± 17

-

FEV1/FVC (%)

36 ± 11 †‡

64 ± 5‡

77 ± 7

79 ± 4

-

PaO2, mmHg

65 ± 14 †‡

81 ± 6

87 ± 8

82 ± 4

-

PaCO2, mmHg

40 ± 6

41 ± 4

40 ± 11

38 ± 3

-

  1. Values are expressed as mean ± SD
  2. †Significantly different from patients with moderate COPD (p < 0.005)
  3. ‡Significantly different from smokers without (w/o) COPD and non-smokers (p < 0.0001)