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Table 1 Clinical Characteristics of Severe Asthma Populationᅟ

From: The relationship between the Leicester cough questionnaire, eosinophilic airway inflammation and asthma patient related outcomes in severe adult asthma

 

Asthma population (n = 262)

Age (years)

54.03 (14.9)

Sex (% male)

37.4

GINA Treatment Stepa

5 (4–5)

Step 4: 124

Step 5: 96

Sputum Eosinophil (%)a

3.5 (0.5-18.75)

% on ICS/LABA combination therapy (number)

94.5 (n = 247)

% on Montelukast (number)

27.1 (n = 71)

% on oral theophylline (number)

32.4 (n = 85)

% on Inhaled Tiotrpoium Bromide (number)

26.0 (n = 68)

% on maintenance oral prednisolone (number)

53.8 (n = 156)

Dose (mg/24 h) in those on Prednisolone

10 (5.0–12.5)a

Self-reported gastrointestinal reflux (%)

49.0

Nasal polyps (%) (number)

26.3 (n = 69)

Perennial/seasonal rhinitis % (number)

58.3 (n = 153)

Smoking history (pack years)

7.2 (2.6–20)

Exacerbations in past year

3 (1.0–6.0)a

ITU admissions in past year

0.0 (0.0–0.0)a

Total ITU admissions

0.0 (0.0–1.0)a

Hospital admissions in past year

0.0 (0.0–1.0)a

Unscheduled GP/A&E visits

3.0 (0.0–7.0)a

Smoking history (pack years)

7.2 (2.6–20)a

Proportion of current: ex smokers

Current smokers: n = 19

Ex-smokers: n = 76

% Smoking >10 pack years (number)

16 .0 (n = 42)

Post Bronchodilator FEV1 (% Predicted)

73.33 (35.7)

Post Bronchodilator FVC (% Predicted)

96.6 (154..4)

Post Bronchodilator FEV1/FVC (%)

66.82 (14.6)

GLI FEV1 Z score

−1.67 (2.68)

Bronchodilator reversibility (%)

14.13 (19.01)

ACQ-6 scorea

2.50 (1.5–3.5)a

AQLQ scorea

3.83 (3.0–5.1)a

LCQ Total scorea

15.48 (11.6–19.2)a

LCQ Total score (females)a

14.9 (10.8–18.7) [n = 164]

LCQ Total Score (males)a

17.1 (12.8–19.8) [n = 98]

LCQ Total score (smoker <10 pack/years)

16.22 (11.3–19.0)

LCQ Total score (smoker ≥10 pack/years)

15.4 (12.7–19.8)

LCQ Physicala

4.75 (3.6–6.0)a

LCQ Psychologicala

5.57 (4.0–6.7)a

LCQ Sociala

5.38 (3.8–6.8)a

  1. GINA Global Initiative for Asthma, ICS/LABA inhaled corticosteroids/long acting beta-2 agonist combination therapy, ITU Intensive care unit, GP General practice, A&E Accident and emergency, FEV 1 Forced Expiratory Volume in one second, FVC Forced Vital Capacity, GLI Global Lung Function Initiative, ACQ-6 Six-point Asthma Control Questionnaire, AQLQ Asthma Quality of Life Questionnaire, LCQ Leicester Cough Questionnaire. Data expressed as mean (standard deviation) or amedian (interquartile range)