Table 6 List of 82 comorbidities included in comorbidity selection, sorted by prevalence (%) in the study population
From: Associations between chronic comorbidity and exacerbation risk in primary care patients with COPD
Comorbiditiy | Prevalence (%) | Diagnosis | ICPC code | Inclusion criteria |
|---|---|---|---|---|
Hypertension | 35.2 | Hypertension | K86, K87 | ICPC code before 1-1-12 |
Coronary heart disease | 19.2 | Myocardial infarction/other ischemic heart disease | K75, K76, K76.02, K76.01 | ICPC code before 1-1-12 |
Angina Pectoris | K74, K74.01, K74.02 | ICPC code before 1-1-12 | ||
Osteoarthritis | 17.6 | Artrose/spondylose wervelkolom | L84, L84.01, L84.02 | ICPC code before 1-1-12 |
Gonartrose | L90 | ICPC code before 1-1-12 | ||
Coxartrose | L89 | ICPC code before 1-1-12 | ||
Osteoarhritis, other | L91 | ICPC code before 1-1-12 | ||
Diabetes | 17.3 | DM1, DM2 | T90, T90.01, T90.02 | ICPC code before 1-1-12 |
Peripheral vascular disease | 14.3 | Atherosclerose | K91 | ICPC code before 1-1-12 |
Intermittent claudication/Raynaud/Buerger | K92, K92.01, K92.02, K92.03 | ICPC code before 1-1-12 | ||
Other disease cardiovascular system | K99, K99.01, K99.02, K 99.03, K99.04, K99.05, K99.06 | ICPC code before 1-1-12 | ||
Blindness & low vision | 13.8 | (Diabetic/hypertensive) retinopathy | F83, F83.01, F83.02 | ICPC code before 1-1-12 |
Maculadegeneratie | F84 | ICPC code before 1-1-12 | ||
Blindness/amblyopia | F94 | ICPC code before 1-1-12 | ||
Cataract | F92, F92.01 | ICPC code before 1-1-12 | ||
Dyspepsia, Gastroesophageal reflux (GERD) | 12.6 | Stomach ulcer | D86.01 | ICPC code before 1-1-12 AND (recode OR connection to episode) 12 months after first ICPC [35] |
Duodenal ulcer | D85 | ICPC code before 1-1-12 AND (recode OR connection to episode) 12 months after first ICPC [35] | ||
Peptic ulcer, other | D86 | ICPC code before 1-1-12 AND (recode OR connection to episode) 12 months after first ICPC [35] | ||
Oesophagus reflux with and without oesophagitis | D87, D87.01, D87.02, D84, D84.02, D84.03 | ICPC code before 1-1-12 AND (recode OR connection to episode) 12 months after first ICPC [35] | ||
Dislipidemia | 11.5 | Hypercholesterolemia/hypertriglyceridemia | T93, T93.01, T93.02, T93.03, T93.04 | ICPC code before 1-1-12 |
Stroke & transient ischaemic attack | 9.7 | TIA (transient ischemic accident) | K89 | ICPC code before 1-1-12 |
CVA (cerebrovascular accident) | K90, K90.01, K90.02, K90.03 | ICPC code before 1-1-12 | ||
Chronic kidney diease | 9.5 | Renal dysfunction | U99, U99.01 | ICPC code before 1-1-12 |
Asthma | 8.5 | Asthma | R96, R96.01, R96.02 | ICPC code before 1-1-2012 AND (recode OR connection to episode) 24 months after first ICPC code [36] |
Hearing loss | 8.1 | Deafness | H84, H86, H85 | ICPC code before 1-1-12 |
Otosclerosis | H83 | ICPC code before 1-1-12 | ||
Heart failure | 7.9 | (congestive) heart failure | K77, K77.01, K77.02 | ICPC code before 1-1-12 |
Pulmonary heart disease | K82 | ICPC code before 1-1-12 | ||
Atrial fibrillation | 7.5 | Atrial fibrillation/flutter | K78 | ICPC code before 1-1-12 |
Skin cancer | 6.3 | Skin cancer | S77.01, S77.02, S77.03, S77.04, S77 | ICPC code before 1-1-12 |
Osteoporosis/osteopenia | 6.3 | Osteoporosis/osteopenie | L95, L95.01, L95.02 | ICPC code before 1-1-12 |
Depression | 5.6 | Depressive disorder | P76, P76.01 | ICPC code before 1-1-2012 AND (recode OR connection to episode) 24 months after first ICPC code [37, 38] |
Thyroid disorder | 5.6 | Hypothyroidism | T86 | ICPC code before 1-1-12 |
Hyperthyroidism | T85 | ICPC code before 1-1-12 | ||
Psoariasis | 4.6 | Psoriasis | S91 | ICPC code before 1-1-12 |
Obesity | 4.4 | Adipositas | T82 | ICPC code before 1-1-12 |
Anxiety | 4.3 | Somatoform disorder | P75 | ICPC code before 1-1-2012 AND (recode OR connection to episode) 24 months after first ICPC code [39] |
Phobia | P79.01 | ICPC code before 1-1-2012 AND (recode OR connection to episode) 24 months after first ICPC code [39] | ||
Anxiety disorder | P74, P 74.01, P74.02 | ICPC code before 1-1-2012 AND (recode OR connection to episode) 24 months after first ICPC code [39] | ||
Obsessive - compulsive disorder | P79.02 | ICPC code before 1-1-2012 AND (recode OR connection to episode) 24 months after first ICPC code [39] | ||
(chronic) functional somatic symtoms | P01, P78 | ICPC code before 1-1-2012 AND (recode OR connection to episode) 24 months after first ICPC code [39] | ||
Post traumatic stress disorder | P02.01 | ICPC code before 1-1-2012 AND (recode OR connection to episode) 24 months after first ICPC code [39] | ||
Eczema | 4.1 | Atopic dermatitis | S87 | ICPC code before 1-1-12 |
Heart valve disease | 3.9 | Heart valve disease | K83, K83.01, K83.02 | ICPC code before 1-1-12 |
Heart valve disease (rheumatic) | K71.02 | ICPC code before 1-1-12 | ||
Diverticular disease of intestine | 3.9 | Colonic diverticula, diverticulitis | D92 | ICPC code before 1-1-12 |
Alcohol problems | 3.9 | Chronic alcohol abuse | P15, P15.01, P15.02, P15.03, P15.04, P15.05, P15.06 | ICPC code before 1-1-12 |
Rheumatoid arthritis, other inflammatory polyarthropathies & systemic connective tissue disorders | 3.7 | Rheumatoid arthritis/ankylosing spondylarthritis | L88.01, L88.02, L88 | ICPC code before 1-1-12 |
Bronchiectasis/chronic bronchitis | 2.8 | Bronchiectasis/Chronic bronchitis | R91.02, R91, R91.01 | ICPC code before 1-1-12 |
Irritable bowel syndrome | 2.8 | Irritable bowel syndrom | D93 | ICPC code before 1-1-12 |
Venous insufficiency | 2.4 | Venous insufficiency | K99.04 | ICPC code before 1-1-12 |
Varicose ulcer | S97, S97.01 | ICPC code AND (recode OR connection to episode) 3 months after first ICPC code [40] | ||
Pulmonary cancer | 2.4 | lung/bronchial cancer | R84 | ICPC code before 1-1-12 |
Recurrent urinary tract infection | 2.3 | Urinary tract infection, chronic/recurrent | U71, U71.01, U71.02 | ICPC code AND (recode OR connection to episode) ≥3 times/year in 2011, 2012, 2013. Years start with 1e ICPC code. Minimal 8 weeks between each episode [41] |
Breast cancer | 2.3 | Breat cancer | X76, X76.01 | ICPC code before 1-1-12 |
Glaucoma | 2.2 | Glaucoma/verhoogde oogboldruk | F93, F93.01, F93.02, F93.03, F93.04 | ICPC code before 1-1-12 |
Gout | 2.0 | Gout | T92 | ICPC code AND (recode OR connection to episode) ≥3 times/year in 2011, 2012, 2013. Years start with 1e ICPC code. Minimal 22 days between each episode [42] |
Prostate cancer | 1.9 | Prostate cancer | Y77 | ICPC code before 1-1-12 |
Dementia | 1.7 | Alzheimer's disease/Senil dementia/Alzheimer/Multi-infarct dementia | P70.01, P70, P70.02 | ICPC code before 1-1-12 |
Colorectal cancer | 1.7 | Colon cancer | D75 | ICPC code before 1-1-12 |
Rectal cancer | D75 | ICPC code before 1-1-12 | ||
Epilepsy | 1.4 | Epilepsy | N88 | ICPC code before 1-1-12 |
Bladder cancer | 1.3 | Bladder cancer | U76 | ICPC code before 1-1-12 |
Sleep apnea syndrome | 1.2 | Sleep apnea syndrome | P0601 | ICPC code before 1-1-12 |
Underfeeding/vitamine deficiency | 1.2 | Underfeeding/vitamine deficiency | T91, T05 | ICPC code before 1-1-12 AND (recode OR connection to episode) 12 months after first ICPC |
Inflammatory bowel disease | 1.2 | Crohn's disease/Ulcerative colitis | D94, D94.01, D94.02 | ICPC code before 1-1-12 |
Personality disorder | 1.2 | Personality disorder | P80, P80.01, P80.02 | ICPC code before 1-1-12 |
Prostate disorders | 1.2 | Prostatic hyperplasia/hypertrophy | Y85 | ICPC code before 1-1-12 |
Other chronic pulmonary disease | 1.1 | Pulmonary tuberculosis | R70 | ICPC code before 1-1-12 |
Pneumoconiosis | R99.06 | ICPC code before 1-1-12 | ||
Sarcoidosis | R83.02 | ICPC code before 1-1-12 | ||
Chronic liver disease | 1 | Cirrose/steatose | D97, D97.04, D97.05 | ICPC code before 1-1-12 |
Genitourinary cancer, other | 0.9 | Genitourinary cancer, other | U75, U77, X77, Y78, Y78.01, Y78.03 | ICPC code before 1-1-12 |
Blood(forming organs) and lymphatics disorder | 0.8 | Benign non specified neoplasm blood/lymphatic disorder | B75 | ICPC code before 1-1-12 AND (recode OR connection to episode) 12 months after first ICPC [43] |
Haemophilia | B83.01 | ICPC code before 1-1-12 | ||
Congenital blood/lymphatic disorder | B79 | ICPC code before 1-1-12 | ||
Purpura/coagulation disorders/abnormal trombocytes | B83, B83.02, B83.06 | ICPC code before 1-1-12 | ||
Schrizophrenia/non-organic psychosis/bipolar disorder | 0.8 | Schizophrenia | P72 | ICPC code before 1-1-12 |
Psychosis non specified | P98 | ICPC code before 1-1-12 | ||
Bipolar | P73.02 | ICPC code before 1-1-12 | ||
Migraine | 0.8 | Migraine | N89 | ICPC code before 1-1-12 AND (recode OR connection to episode) 12 months after first ICPC [44] |
Cancer oropharynx, oesophageal, stomach | 0.8 | Cancer of the mouth/pharynx | D77.02, D77.03 | ICPC code before 1-1-12 |
Oesophageal cancer | D77.01, D77 | ICPC code before 1-1-12 | ||
Cancer of stomach | D74 | ICPC code before 1-1-12 | ||
Other psychoactive substance misuse | 0.7 | Substance abuse | P19, P19.01, P19.02 | ICPC code before 1-1-12 |
Parkinson's disease | 0.6 | Parkinson's disease | N87.01, N87 | ICPC code before 1-1-12 |
Other chronic skin disease/neoplasm (sub)cutis | 0.6 | Neoplasm cutis, subcutis non specified | S80, S80.01, S81, S83, S83.01, S83.02 | ICPC code before 1-1-12 |
Vitiligo/lichen planus | S99.04, S99.06 | ICPC code before 1-1-12 | ||
Viral hepatitis | 0.6 | Hepatitis B | D72.02, D72.04 | ICPC code before 1-1-12 |
Hepatitis C | D72.03, D72.05 | ICPC code before 1-1-12 | ||
Hepatitis | D72 | ICPC code before 1-1-12 | ||
Uterine cervical cancer | 0.5 | Uterine cervical cancer | X75 | ICPC code before 1-1-12 |
Learning disability’/Mental retardation | 0.4 | Mental retardation | P85 | ICPC code before 1-1-12 |
Specified learning problems | P24. P24.01, P24.02, P24.03 | ICPC code before 1-1-12 | ||
Laryngeal/throat cancer | 0.4 | Laryngeal/troat cancer | R85 | ICPC code before 1-1-12 |
Hodgkin disease | 0.4 | Hodgkin disease | B72, B72.01, B72.02 | ICPC code before 1-1-12 |
Carcinoma, other | 0.4 | Carcinoma, other | D77.04, T71, W72, L71, L71.01 | ICPC code before 1-1-12 |
Chronic sinusitis | 0.3 | Chronic sinusitis | R75.02 | ICPC code before 1-1-12 |
Acute Sinusitis | R75.01 en R75 | ICPC code AND (recode OR connection to episode) ≥3×/year in 2011, 2012, 2013. Years start with 1e ICPC code. Minimal 29 days between each episode. [45] | ||
Glomerulonephritis/nephrosis | 0.3 | Glomerulonephritis | U88 | ICPC code before 1-1-12 |
Congenital cardiovascular anomaly | 0.2 | Congenital cardiovascular anomaly | K73, K73.01, K73.02 | ICPC code before 1-1-12 |
Leukaemia | 0.2 | Leukaemia | B73 | ICPC code before 1-1-12 |
Lymphoma/multiple myeloma/other blood cancer | 0.2 | Lymphoma/multiple myeloma/other blood cancer | B74.01, B74 | ICPC code before 1-1-12 |
Anaemia | 0.1 | Pernicous/folic acid anaemia | B81, B81.01, B81.02 | ICPC code before 1-1-12 AND (recode OR connection to episode) 12 months after first ICPC [43] |
Haemolytic anaemia | B78, B78.01, B78.02, B78.03 | ICPC code before 1-1-12 | ||
Anorextia or bulimia | 0.1 | Anorexia nervosa | T06, T06.01, T06.02 | ICPC code before 1-1-12 |
Coeliakie | 0.1 | Coeliakie | D99.06 | ICPC code before 1-1-12 |
Endometrial cancer | 0.1 | Endometrial cancer | X77.01 | ICPC code before 1-1-12 |
Metastases; unknown origin | 0.1 | Metastases; unknown origin | A79 | ICPC code before 1-1-12 |
Multiple sclerosis | 0.1 | MS (multiple sclerosis) | N86 | ICPC code before 1-1-12 |
Ovarian cancer | 0.1 | Ovarian cancer | X77.02 | ICPC code before 1-1-12 |
Pancreatic cancer | 0.1 | Pancreatic cancer | D76 | ICPC code before 1-1-12 |
Testis cancer | 0.1 | Testis cancer | Y78.02 | ICPC code before 1-1-12 |
Brain cancer (recall: Nervous system cancer) | 0 | Brain cancer (recall: Nervous system cancer) | N74 | ICPC code before 1-1-12 |
HIV/AIDS | 0 | HIV; AIDS | B90, B90.01, B90.02 | ICPC code before 1-1-12 |