Table 3 Main clinical characteristics of the study population, by phenotype/subgroup
Phenotype/subgroup | Chronic bronchitis/emphysema (n = 15) | Emphysema (n = 30) | Obstructive (n = 7) | Smoking control (n = 25) | Never-smoking control (n = 12) | Total n = 89 |
|---|---|---|---|---|---|---|
Mean age, years (IQR) | 66.3 (59.5–72.5) | 70.5 (67–76.5 | 71.4 (67–72.5) | 64.2 (56–71) | 62.3 (54–69.3) | 66.7 (60.3–74) |
Male sex, n (%) | 7 (46.7) | 16 (53.3) | 4 (57.1) | 5 (20) | 4 (33.3) | 35 (39.3) |
Current smokers, n (%) | 3 (20) | 1 (3.3) | 1 (14.3) | 12 (48) | 0 (0) | 17 (19.1) |
BMI (kg/m2) | 30.1 (8.5) | 29.5 (10.5) | 27.1 (4.2) | 30.4 (10.9) | 24.8 (3.6) | 29.0 (9.4) |
GOLD stage n, %) | Â | Â | Â | N/A | Â | |
 1 | 3 (20.0) | 2 (6.7) | 2 (28.5) | 7 (7.9) | ||
 2 | 2 (13.3) | 11 (36.7) | 3 (42.9) | 16 (18.0) | ||
 3 | 3 (20.0) | 7 (23.3) | 2 (28.6) | 12 (13.5) | ||
 4 | 7 (46.7) | 9 (30.0) | 0 (0) | 16 (18.0) | ||
 N/A | 0 (0) | 1 (3.3) | 0 (0) | 1 (1.1) | ||
FEV1, liters (SD) | 1.29 (0.80) | 1.39 (0.61) | 2.16 (0.88) | 2.51 (0.73) | 2.80 (0.80) | 1.95 (0.95) |
FEV1, % of predicted (SD) | 46.9 (29.9) | 62.8 (95.4) | 65.1 (17.2) | 90.2 (17.5) | 97.2 (12.4) | 83.1 (47.6) |
FVC, liters (SD) | 2.77 (1.00) | 2.54 (0.98) | 3.32 (1.27) | 3.17 (0.90) | 3.42 (0.86) | 2.94 (1.02) |
FVC, % of predicted (SD) | 74.9 (37.2) | 79.7 (74.4) | 73.9 (18.6) | 92.0 (12.4) | 85.7 (28.0) | 83.1 (48.6) |
FEV1/FVC ratio | 0.43 (0.14) | 0.49 (0.12) | 0.65 (0.02) | 0.79 (0.06) | 0.81 (0.04) | 0.62 (0.19) |
6 MWD, meters (SD) | 298 (162) | 317 (162) | 415 (139) | 421 (104) | 527 (85) | 391 (137) |
SF36 PCS | 33.3 (10.2) | 36.7 (10.0) | 41.0 (11.5) | 49.3 (8.9) | 54.0 (5.2) | 42.4 (12.0) |
SF36 MCS | 47.6 (9.9) | 55.0 (8.1) | 58.9 (3.0) | 50.9 (12.8) | 56.0 (6.6) | 53.1 (10.1) |