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Table 3 Main clinical characteristics of the study population, by phenotype/subgroup

From: Biomarkers of extracellular matrix turnover are associated with emphysema and eosinophilic-bronchitis in COPD

Phenotype/subgroup Chronic bronchitis/emphysema
(n = 15)
Emphysema
(n = 30)
Obstructive
(n = 7)
Smoking control
(n = 25)
Never-smoking control
(n = 12)
Total
n = 89
Mean age, years (IQR) 66.3 (59.5–72.5) 70.5 (67–76.5 71.4 (67–72.5) 64.2 (56–71) 62.3 (54–69.3) 66.7 (60.3–74)
Male sex, n (%) 7 (46.7) 16 (53.3) 4 (57.1) 5 (20) 4 (33.3) 35 (39.3)
Current smokers, n (%) 3 (20) 1 (3.3) 1 (14.3) 12 (48) 0 (0) 17 (19.1)
BMI (kg/m2) 30.1 (8.5) 29.5 (10.5) 27.1 (4.2) 30.4 (10.9) 24.8 (3.6) 29.0 (9.4)
GOLD stage n, %)     N/A  
 1 3 (20.0) 2 (6.7) 2 (28.5) 7 (7.9)
 2 2 (13.3) 11 (36.7) 3 (42.9) 16 (18.0)
 3 3 (20.0) 7 (23.3) 2 (28.6) 12 (13.5)
 4 7 (46.7) 9 (30.0) 0 (0) 16 (18.0)
 N/A 0 (0) 1 (3.3) 0 (0) 1 (1.1)
FEV1, liters (SD) 1.29 (0.80) 1.39 (0.61) 2.16 (0.88) 2.51 (0.73) 2.80 (0.80) 1.95 (0.95)
FEV1, % of predicted (SD) 46.9 (29.9) 62.8 (95.4) 65.1 (17.2) 90.2 (17.5) 97.2 (12.4) 83.1 (47.6)
FVC, liters (SD) 2.77 (1.00) 2.54 (0.98) 3.32 (1.27) 3.17 (0.90) 3.42 (0.86) 2.94 (1.02)
FVC, % of predicted (SD) 74.9 (37.2) 79.7 (74.4) 73.9 (18.6) 92.0 (12.4) 85.7 (28.0) 83.1 (48.6)
FEV1/FVC ratio 0.43 (0.14) 0.49 (0.12) 0.65 (0.02) 0.79 (0.06) 0.81 (0.04) 0.62 (0.19)
6 MWD, meters (SD) 298 (162) 317 (162) 415 (139) 421 (104) 527 (85) 391 (137)
SF36 PCS 33.3 (10.2) 36.7 (10.0) 41.0 (11.5) 49.3 (8.9) 54.0 (5.2) 42.4 (12.0)
SF36 MCS 47.6 (9.9) 55.0 (8.1) 58.9 (3.0) 50.9 (12.8) 56.0 (6.6) 53.1 (10.1)
  1. Data are presented as mean (SD), unless stated otherwise. IQR Inter-Quartile Range, BMI Body Mass Index, FEV 1 Forced Expiratory Volume in 1 s, FVC Forced Vital Capacity, 6MWD 6 min Walking Distance, SF-36 PCS Physical Component Score of the SF 36 quality of life psychometric tool, SF 36 MCS Mental Component Score of the SF 36 quality of life psychometric tool. Higher score reflects better health