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Table 1 Overview of biomarkers measured, description and biological relevance

From: Biomarkers of extracellular matrix turnover are associated with emphysema and eosinophilic-bronchitis in COPD

  Biomarker description Biological relevance References
C1M Fragment of type I collagen degraded by MMPs Inflammatory interstitial matrix destruction [46]
C6M Fragment of type VI collagen degraded by MMPs Inflammatory interstitial matrix destruction [70]
Pro-C6 Pro-peptide of type VI collagen Formation of new interstitial matrix [66]
EL-NE Fragment of elastin degraded by neutrophil elastase Inflammatory destruction of interstitial matrix [50]
  1. MMP matrix metalloproteinase