Biomarkers of extracellular matrix turnover are associated with emphysema and eosinophilic-bronchitis in COPD

Respiratory Research

Table 1 Overview of biomarkers measured, description and biological relevance

	Biomarker description	Biological relevance	References
C1M	Fragment of type I collagen degraded by MMPs	Inflammatory interstitial matrix destruction	[46]
C6M	Fragment of type VI collagen degraded by MMPs	Inflammatory interstitial matrix destruction	[70]
Pro-C6	Pro-peptide of type VI collagen	Formation of new interstitial matrix	[66]
EL-NE	Fragment of elastin degraded by neutrophil elastase	Inflammatory destruction of interstitial matrix	[50]

ISSN: 1465-993X