Admission levels of asymmetric and symmetric dimethylarginine predict long-term outcome in patients with community-acquired pneumonia

Vögeli, Alaadin; Ottiger, Manuel; Meier, Marc A.; Steuer, Christian; Bernasconi, Luca; Kulkarni, Prasad; Huber, Andreas; Christ-Crain, Mirjam; Henzen, Christoph; Hoess, Claus; Thomann, Robert; Zimmerli, Werner; Mueller, Beat; Schuetz, Philipp

doi:10.1186/s12931-017-0502-4

Table 3 Univariate association of initial biomarker levels with demographic characteristics and comorbidities

From: Admission levels of asymmetric and symmetric dimethylarginine predict long-term outcome in patients with community-acquired pneumonia

	Arginine		ADMA		SDMA		Arginine/ADMA ratio
	Coefficient (95% CI)	p value	Coefficient (95% CI)	p value	Coefficient (95% CI)	p value	Coefficient (95% CI)	p value
Patient characteristics
Age in decades	0.01 (−0.01 to 0.03)	0.246	0.03 (0.01 to 0.04)	<0.001	0.07 (0.05 to 0.10)	<0.001	−0.07 (−0.10 to −0.04)	<0.001
Female	−0.02 (−0.09 to 0.05)	0.546	0.001 (−0.05 to 0.05)	0.958	−0.01 (−0.11 to 0.09)	0.856	−0.01 (−0.12 to 0.10)	0.830
BMI	−0.01 (−0.01 to 0.001)	0.065	0.002 (−0.003 to 0.01)	0.361	0.0001 (−0.01 to 0.01)	0.971	−0.01 (−0.02 to 0.01)	0.297
Systolic blood pressure in 10 mmHg	0.01 (0.0004 to 0.03)	0.143	−0.01 (−0.02 to 0.005)	0.260	−0.02 (−0.04 to −0.004)	0.020	0.03 (0.01 to 0.06)	0.005
Comorbidities
Coronary artery disease	−0.08 (−0.17 to 0.01)	0.076	−0.01 (−0.08 to 0.05)	0.719	0.15 (0.03 to 0.27)	0.014	−0.26 (−0.39 to −0.13)	<0.001
Congestive heart failure	−0.01 (−0.12 to 0.10)	0.851	0.05 (−0.03 to 0.12)	0.204	0.17 (0.03 to 0.31)	0.017	−0.22 (−0.38 to −0.06)	0.007
Cerebrovascular disease	0.10 (−0.02 to 0.22)	0.091	0.05 (−0.04 to 0.13)	0.272	0.15 (−0.004 to 0.31)	0.057	−0.08 (−0.26 to 0.10)	0.387
PAOD	0.05 (−0.11 to 0.20)	0.546	−0.01 (−0.11 to 0.10)	0.901	0.15 (−0.05 to 0.35)	0.133	−0.13 (−0.35 to 0.10)	0.274
Chronic renal failure	0.02 (−0.06 to 0.11)	0.603	0.07 (0.01 to 0.12)	0.027	0.32 (0.22 to 0.43)	<0.001	−0.32 (−0.44 to −0.20)	<0.001
Diabetes mellitus	0.05 (−0.05 to 0.14)	0.362	0.06 (−0.01 to 0.13)	0.111	0.15 (0.02 to 0.28)	0.021	−0.14 (−0.29 to 0.01)	0.064
Neoplastic disease	0.03 (−0.08 to 0.14)	0.578	0.10 (0.03 to 0.17)	0.008	0.17 (0.02 to 0.31)	0.022	−0.16 (−0.32 to 0.01)	0.060
COPD	−0.01 (−0.09 to 0.07)	0.790	−0.03 (−0.08 to 0.03)	0.361	0.17 (0.06 to 0.27)	0.002	−0.18 (−0.30 to −0.06)	0.004

Data for univariate linear regression analyses are given as coefficient (95% CI)
Bolded p values are statistically significant at p < 0.05
Abbreviations: ADMA asymmetric dimethylarginine, BMI body mass index, CI confidence interval, COPD chronic obstructive pulmonary disease, PAOD peripheral artery occlusive disease, SDMA symmetric dimethylarginine

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ISSN: 1465-993X

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