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Table 2 Association of initial biomarker levels with all-cause mortality at different time points

From: Admission levels of asymmetric and symmetric dimethylarginine predict long-term outcome in patients with community-acquired pneumonia

 

All-cause mortality time point

Entire Cohort (N = 268)

30 day

1 year

6 years

Cox regression models

HR (95% CI); p value

Arginine

   

 Univariate

1.04 (0.17 to 6.31); p = 0.968

2.19 (0.71 to 6.79); p = 0.175

1.10 (0.56 to 2.15), p = 0.791

 Multivariatea

1.08 (0.14 to 8.45); p = 0.942

2.53 (0.74 to 8.74); p = 0.141

1.12 (0.52 to 2.41); p = 0.764

 AUC

0.52 (0.33 to 0.71)

0.56 (0.46 to 0.66)

0.50 (0.43 to 0.57)

ADMA

   

 Univariate

10.47 (0.72 to 152.55); p = 0.086

7.22 (1.81 to 28.77); p  = 0.005

4.44 (1.84 to 10.74); p  = 0.001

 Multivariatea

5.79 (0.29 to 116.72); p = 0.252

3.33 (0.72 to 15.39); p = 0.124

1.91 (0.73 to 5.00); p = 0.188

 AUC

0.67 (0.52 to 0.82)

0.67 (0.58 to 0.75)

0.65 (0.58 to 0.72)

SDMA

   

 Univariate

15.79 (2.23 to 112.02); p  = 0.006

5.62 (1.92 to 16.46); p  = 0.002

2.81 (1.45 to 5.48); p  = 0.002

 Multivariatea

2.78 (0.17 to 44.74); p = 0.471

1.22 (0.39 to 3.86); p = 0.736

0.82 (0.44 to 1.52); p = 0.523

 AUC

0.71 (0.56 to 0.87)

0.70 (0.61 to 0.8)

0.64 (0.57 to 0.71)

Arginine/ADMA Ratio

   

 Univariate

0.36 (0.04 to 3.78); p = 0.398

0.44 (0.13 to 1.54); p = 0.198

0.33 (0.15 to 0.74); p  = 0.007

 Multivariatea

0.93 (0.12 to 7.31); p = 0.944

1.25 (0.33 to 4.68); p = 0.741

0.84 (0.36 to 1.93); p = 0.675

 AUC

0.44 (0.25 to 0.63)

0.43 (0.32 to 0.53)

0.39 (0.32 to 0.46)

  1. Data for univariate and multivariate Cox regression models are given as hazard ratio (95% CI); p value
  2. Data regarding discrimination (prognostic accuracy) are given as area under the receiver operating characteristic curve (95% CI)
  3. P values in bold type are statistically significant at p < 0.05
  4. Abbreviations: ADMA Asymmetric Dimethylarginine, AUC area under the receiver operating characteristics curve, CI confidence interval, HR hazard ratio, SDMA Symmetric Dimethylarginine
  5. aMultivariate model: Admission concentration of logarithmic biomarkers adjusted for comorbidities (coronary artery disease, congestive heart failure, cerebrovascular disease, peripheral artery occlusive disease, diabetes mellitus, chronic renal failure, neoplastic disease, and chronic obstructive pulmonary disease) and age