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Table 1 Correlation between NKA concentrations and levels of pro-oxidant factors, anti-oxidant factors and cytokines after overnight incubation with LPS (100 ng/ml)

From: Pharmacological investigation on the anti-oxidant and anti-inflammatory activity of N-acetylcysteine in an ex vivo model of COPD exacerbation

NKA vs:

Pearson r

95% CI

P

Peroxidase activity

0.85

0.47 - 0.96

***

H2O2

0.84

0.44 - 0.96

**

MDA

0.63

0.01 - 0.90

*

NO

0.83

0.41 - 0.96

**

TAC

−0.49

−0.86 - 0.20

ns

GSH

−0.63

−0.91 - 0.058

*

SOD

−0.28

−0.77 - 0.43

ns

IL-1β

0.13

−0.55 - 0.70

ns

IL-6

0.82

0.4 0–0.96

**

IL-8

0.30

−0.40 - 0.78

ns

TNF-α

0.19

−0.50 - 0.73

ns

  1. * P<0.05, ** P<0.01, *** P<0.001, ns: not significant. GSH glutathione, IL interleukin, MDA malondialdehyde, NKA neurokinin A, NO nitric oxide, ROS reactive oxygen species, SOD superoxide dismutase, TAC total anti-oxidant capacity, TNF-α tumor necrosis factor-α