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Table 4 Top SNPs (n = 14) associated with phlegm in the GWA study (all P < 1.0 × 10−4)

From: No convincing association between genetic markers and respiratory symptoms: results of a GWA study

SNPs

Chr

Gene

A1

MAF

Identification LifeLines I

Replication

Meta-analysis Replication

LifeLines II

Vlagtwedde-Vlaardingen

OR

P

OR

P

OR

P

OR

P

rs4818199

21

79 kb 3′ of NCRNA00323

T

0.40

0.781

3.28E-06

0.936

0.314

1.048

0.711

0.959

0.470

rs13285576

9

488 kb 3′ of CYLC2

A

0.16

0.724

1.68E-05

1.022

0.800

0.847

0.324

0.986

0.827

rs6828886

4

171 kb 3′ of PAPSS1

C

0.42

0.794

1.81E-05

0.982

0.780

1.035

0.789

0.993

0.904

rs6040994

20

30 kb 3′ of BTBD3

T

0.15

1.371

1.93E-05

0.930

0.481

1.055

0.794

0.954

0.607

rs9643995

8

SGCZ

T

0.03

0.471

2.79E-05

1.402

0.028

0.987

0.971

1.331

0.049

rs9831020

3

107 kb 3′ of LOC100507098

G

0.13

0.691

4.44E-05

1.014

0.892

0.988

0.948

1.008

0.933

rs7680755

4

230 kb 3′ of PAPSS1

T

0.41

0.801

4.66E-05

0.982

0.789

1.030

0.815

0.992

0.896

rs17534243

1

24 kb 3′ of LOC339442

G

0.21

1.265

4.91E-05

0.954

0.546

0.911

0.538

0.945

0.412

rs1156855

15

PAQR5

A

0.39

0.809

5.25E-05

1.026

0.700

1.221

0.126

1.063

0.300

rs6075458

20

145 kb 5′ of SLC24A3

A

0.20

0.759

5.79E-05

1.035

0.676

1.051

0.742

1.039

0.598

rs17792478

6

SENP6

G

0.33

1.233

5.92E-05

1.086

0.219

0.896

0.390

1.042

0.488

rs8025182

15

PAQR5

T

0.39

0.812

6.79E-05

1.016

0.812

1.269

0.063

1.064

0.289

rs6786757

3

SLC9A9

G

0.09

1.411

8.57E-05

1.136

0.290

1.092

0.714

1.127

0.266

rs7633390

3

27 kb 5′ of ZNF717

T

0.20

1.255

9.25E-05

0.970

0.691

0.994

0.967

0.975

0.710