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Table 3 Top SNPs (n = 19) associated with dyspnea in the GWA study (all P < 1.0 × 10−4)

From: No convincing association between genetic markers and respiratory symptoms: results of a GWA study

SNPs

Chr

Gene

A1

MAF

Identification LifeLines I

Replication

Meta-analysis Replication

LifeLines II

Vlagtwedde-Vlaardingen

OR

P

OR

P

OR

P

OR

P

rs10754237

1

LHX9

T

0.03

1.883

1.80E-06

0.921

0.642

1.523

0.057

1.120

0.412

rs658121

18

LAMA1

T

0.14

1.349

2.70E-06

1.039

0.638

0.776

0.070

0.965

0.614

rs6428425

1

8.1 kb 3′ of LHX9

G

0.97

1.864

2.90E-06

0.912

0.602

1.528

0.056

1.067

0.395

rs13388308

2

ATF2

T

0.19

0.751

4.59E-06

0.997

0.961

0.939

0.581

0.980

0.739

rs7236872

18

208 kb 3′ of CBLN2

A

0.53

1.237

7.79E-06

1.033

0.583

0.956

0.626

1.010

0.834

rs2243335

21

324 kb 5′ of MIR802

C

0.30

0.790

9.91E-06

1.014

0.821

1.077

0.438

1.032

0.540

rs4599120

2

4.3 kb 3′ of LOC84931

A

0.08

1.390

2.11E-05

0.942

0.551

0.895

0.466

0.927

0.368

rs12698902

7

AUTS2

G

0.27

1.239

3.73E-05

1.052

0.425

1.141

0.192

1.077

0.170

rs6977656

7

AUTS2

T

0.19

1.267

4.05E-05

1.065

0.375

1.109

0.358

1.077

0.214

rs2898237

21

329 kb 5′ of MIR802

G

0.30

0.805

4.21E-05

1.025

0.689

1.120

0.228

1.053

0.318

rs10231884

7

LOC100505881

A

0.58

0.817

4.61E-05

0.998

0.972

0.961

0.666

0.987

0.793

rs13232100

7

AUTS2

G

0.40

1.217

4.92E-05

1.036

0.544

1.130

0.197

1.062

0.233

rs11154774

6

22 kb 3′ of LOC154092

G

0.40

1.215

5.25E-05

1.083

0.173

1.083

0.173

1.081

0.113

rs7642234

3

DNAH12

A

0.26

1.253

6.30E-05

0.943

0.402

1.047

0.675

0.972

0.653

rs836692

2

30 kb 5′ of B3GALT1

T

0.32

1.225

6.44E-05

1.048

0.453

1.074

0.456

1.056

0.303

rs6852190

4

LIMCH1

T

0.36

0.813

6.88E-05

1.202

0.002

0.981

0.845

1.135

0.014

rs2063621

3

CADPS

G

0.78

0.797

6.94E-05

1.108

0.125

1.142

0.212

1.118

0.049

rs10180670

2

225 kb 5′ of SOX11

A

0.17

0.775

7.00E-05

0.987

0.859

0.956

0.682

0.978

0.708

rs1391412

16

294 kb 3′ of TERF2IP

A

0.44

0.826

8.37E-05

1.047

0.429

1.010

0.915

1.036

0.473

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Respiratory Research

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