No convincing association between genetic markers and respiratory symptoms: results of a GWA study

Respiratory Research

Table 2 Top SNPs (n = 17) associated with cough in the GWA study (all P < 1.0 × 10⁻⁴)

SNPs	Chr	Gene	A1	MAF	Identification LifeLines I		Replication				Meta-analysis Replication
					Identification LifeLines I		LifeLines II		Vlagtwedde-Vlaardingen		Meta-analysis Replication
					OR	P	OR	P	OR	P	OR	P
rs11813494	10	638 kb 3′ of SFTA1P	G	0.24	1.279	1.12E-06	1.110	0.114	0.776	0.096	1.049	0.427
rs840952	2	60 kb 5′ of SPRED2	G	0.10	1.212	1.09E-05	1.168	0.006	0.814	0.169	1.035	0.401
rs7633390	3	27 kb 5′ of ZNF717	T	0.18	1.237	2.24E-05	1.037	0.581	0.865	0.305	1.005	0.938
rs4977230	9	SLC24A2	T	0.71	0.817	3.35E-05	1.020	0.744	0.986	0.910	1.013	0.806
rs4780334	16	CIITA	G	0.69	1.209	3.78E-05	0.985	0.802	0.875	0.295	0.964	0.500
rs844033	15	126 kb 5′ of NDN	C	0.91	0.702	3.84E-05	1.163	0.115	1.213	0.342	1.172	0.068
rs422564	5	3.9 kb 3′ of TBCA	T	0.21	1.201	3.97E-05	1.035	0.549	1.196	0.123	1.065	0.222
rs12153520	5	77 kb 3′ of HINT1	A	0.16	1.259	4.48E-05	1.012	0.875	1.020	0.904	1.013	0.844
rs893966	1	EPHB2	T	0.50	1.248	4.72E-05	0.992	0.909	0.909	0.532	0.975	0.707
rs6775462	3	ROBO2	C	0.50	0.739	4.81E-05	0.952	0.588	1.124	0.497	0.987	0.869
rs4766584	12	ACACB	G	0.45	0.821	5.15E-05	0.929	0.234	0.994	0.964	0.941	0.274
rs16918212	12	A2MP1	A	0.20	0.717	5.41E-05	0.882	0.196	0.613	0.021	0.828	0.033
rs2623166	8	GEM	T	0.13	1.293	7.68E-05	0.994	0.948	0.635	0.029	0.928	0.360
rs17729233	18	DSG4	G	0.44	1.257	7.89E-05	1.034	0.668	0.997	0.982	1.026	0.714
rs2850106	21	HLCS	G	0.12	0.839	8.29E-05	1.050	0.384	0.998	0.989	1.040	0.434
rs10758982	9	PTPRD	G	0.34	1.211	8.36E-05	0.967	0.602	0.827	0.163	0.939	0.284
rs2845804	21	HLCS	C	0.18	0.841	9.93E-05	0.976	0.663	1.090	0.461	0.996	0.941

ISSN: 1465-993X