Skip to main content

Table 2 Genes showing 10-fold or greater changes in gene expression between the IPF and control groups

From: Gene profile of fibroblasts identify relation of CCL8 with idiopathic pulmonary fibrosis

N

Gene Name

IPF (mean ± SE)

Controls (mean ± SE)

TNoM (p-value)

t-test (p-value)

FC

1

PF4V1

63.21 ± 18.03

1.07 ± 0.27

0.048

0.039

59.2

2

MYOC

18.5 ± 5.76

0.74 ± 0.24

0.048

0.018

25.1

3

CCL8

121.72 ± 45.48

5.33 ± 0.87

0.004

0.038

22.8

4

ROR2

70.83 ± 25.7

3.2 ± 2.7

0.048

0.034

22.1

5

HBG2

155.74 ± 48.34

8.07 ± 7.48

0.048

0.019

19.3

6

D4S234E

75.89 ± 21.97

4.04 ± 3.54

0.048

0.048

18.8

7

KCNJ2

111.29 ± 30.99

5.97 ± 2.12

0.004

0.011

18.6

8

RGS18

33.44 ± 12.08

1.99 ± 1.3

0.048

0.035

16.8

9

PITX1

592.66 ± 233.64

41.31 ± 14.57

0.048

0.05

14.3

10

EPB41L3

180.61 ± 52.92

12.91 ± 6.88

0.048

0.016

14.0

11

FGF7

31.28 ± 7.5

2.79 ± 1.17

0.004

0.007

11.2

12

LOC100132994

5.56 ± 1.38

0.5 ± 0.0

0.048

0.03

11.1

13

POSTN

88.86 ± 22.25

8.64 ± 7.85

0.048

0.009

10.3

14

FLJ25037

0.82 ± 0.21

8.79 ± 2.45

0.048

0.047

−10.8

15

IGFBP2

5.3 ± 1.18

60.29 ± 16.59

0.004

0.045

−11.4

  1. Messenger RNA band intensity was quantified using GenomeStudio software (v. 2011.1; Illumina, Inc., San Diego, CA, USA) and the Gene Expression Module. Data were presented as the means ± standard error (SE). Gene expression fold-change was calculated as follows: if the mean level was higher in patients with IPF than in controls, the level in IPF fibroblasts was divided by that in control fibroblasts. In the reverse case (control higher than IPF levels), the mean value of the control group was divided by that of the IPF group and presented as a negative value. P-values were calculated using the nonparametric Threshold Number of Misclassifications (TNoM) scoring method and t-tests, and values less than 0.05 were considered significant