Fig. 1

Patient disposition. In Part A, patients were randomized to receive any of the eight treatments in each of the four periods of the study in an incomplete block crossover design. In Part B, patients were randomized to receive all three formoterol doses and placebo in each of the four periods of the study in a full crossover design. ^aFive patients met multiple criteria for exclusion from randomization (not meeting inclusion criteria and/or meeting exclusion criteria). ^bPatients randomized to treatment, who received at least one dose of study drug. ^cPatients who completed at least two treatment periods with at least 2 h of post-dose data on Day 7, with no more than one missing data-point from 15 min to 2 h post-dose, inclusive. COPD, chronic obstructive pulmonary disease; CT, computed tomography; ITT, intent-to-treat; LRTI, lower respiratory tract infection; mITT, modified ITT