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Fig. 5 | Respiratory Research

Fig. 5

From: Regulatory T cells and IL10 suppress pulmonary host defense during early-life exposure to radical containing combustion derived ultrafine particulate matter

Fig. 5

Effect of IL10 deficiency on the morbidity and pulmonary viral load in EPFR-exposed neonatal mice. a Average percent body weight change ((value-baseline/baseline)*100) in WT and IL10−/− mice exposed to Air or DCB. b Immunohistochemical staining for influenza virus representing the pulmonary viral load at 4 dpi in WT and IL10−/− mice exposed to Air or DCB. c Pulmonary viral load at 4 dpi in WT and IL10−/− mice exposed to Air or DCB and infected with influenza virus. Limit of detection is indicated by dotted line. Data were plotted as means ± SEM; *p < 0.05, WT (Air/Flu) vs WT (DCB/Flu), IL10−/− (Air/Flu) vs IL10−/− (DCB/Flu), WT (Air/Flu) vs IL10−/− (Air/Flu), and IL10−/− (Air/Flu) vs WT (DCB/Flu); # p < 0.05, WT (DCB/Flu) vs IL10−/− (DCB/Flu) on indicated dpi. a Multiple comparisons t tests with Holm-Sidak correction for multiple comparisons (c) Two-way ANOVA with Holm-Sidak correction for multiple comparisons test

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Respiratory Research

ISSN: 1465-993X

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