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Fig. 2 | Respiratory Research

Fig. 2

From: Regulatory T cells and IL10 suppress pulmonary host defense during early-life exposure to radical containing combustion derived ultrafine particulate matter

Fig. 2

Depletion of Tregs in the lungs of DCB-exposed neonatal mice enhances adaptive T cell responses. a Schematic for DCB exposure, influenza infection, administration of anti-CD25 (PC61 clone) monoclonal antibody or rat IgG isotype control, and the analysis of adaptive T cell responses at 6 dpi. b Percentage of CD8+ cells expressing IFNγ (Tc1) and representative flow contour plots in Air/Flu, DCB/Flu, DCB/Isotype/Flu, and DCB/PC61/Flu mice. c Percentage of CD4+ cells expressing IFNγ (Th1) and representative flow contour plots in Air/Flu, DCB/Flu, DCB/Isotype/Flu, and DCB/PC61/Flu mice. *p < 0.05. Data were plotted as mean ± SEM. One-way ANOVA with Tukey’s multiple comparison test

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Respiratory Research

ISSN: 1465-993X

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