Table 5 The pathway enrichment of dysregulated mRNAs regulated by miRNAs
miRNA | Pathway | Genes | Gene Ratio | P Value |
|---|---|---|---|---|
miR-24-3p | Rheumatoid arthritis | IL1A/CCL3/CCL3L3/IL18/IL1B/TNF | 6/16 | 2.37E-06 |
African trypanosomiasis | HBA2/IL18/IL1B/TNF | 4/16 | 2.47E-05 | |
Cytokine-cytokine receptor interaction | IL1A/CCL3/CCL4/CCL3L3/IL18/IL1B/TNF | 7/16 | 2.53E-05 | |
Malaria | HBA2/IL18/IL1B/TNF | 4/16 | 5.74E-05 | |
Toll-like receptor signaling pathway | CCL3/CCL4/IL1B/TNF | 4/16 | 0.000645 | |
Chagas disease (American trypanosomiasis) | CCL3/CCL3L3/IL1B/TNF | 4/16 | 0.000645 | |
Graft-versus-host disease | IL1A/IL1B/TNF | 3/16 | 0.000741 | |
Type I diabetes mellitus | IL1A/IL1B/TNF | 3/16 | 0.000743 | |
Cytosolic DNA-sensing pathway | CCL4/IL18/IL1B | 3/16 | 0.001268 | |
NOD-like receptor signaling pathway | IL18/IL1B/TNF | 3/16 | 0.001331 | |
miR-320a | Natural killer cell mediated cytotoxicity | ICAM1/KIR2DL2/TNF | 3/8 | 0.018267 |
African trypanosomiasis | ICAM1/TNF | 2/8 | 0.018267 | |
Graft-versus-host disease | KIR2DL2/TNF | 2/8 | 0.018382 | |
Malaria | ICAM1/TNF | 2/8 | 0.01936 | |
RIG-I-like receptor signaling pathway | TANK/TNF | 2/8 | 0.029778 | |
Antigen processing and presentation | KIR2DL2/TNF | 2/8 | 0.029845 | |
Rheumatoid arthritis | ICAM1/TNF | 2/8 | 0.035321 | |
Folate biosynthesis | GCH1 | 1/8 | 0.072257 | |
Asthma | TNF | 1/8 | 0.150454 | |
Graft-versus-host disease | GZMB/KIR2DL2/TNF | 3/7 | 0.000379 | |
miR-320b | Graft-versus-host disease | GZMB/KIR2DL2/TNF | 3/7 | 0.000379 |
Natural killer cell mediated cytotoxicity | GZMB/KIR2DL2/TNF | 3/7 | 0.005999 | |
Allograft rejection | GZMB/TNF | 2/7 | 0.008916 | |
Type I diabetes mellitus | GZMB/TNF | 2/7 | 0.008916 | |
Antigen processing and presentation | KIR2DL2/TNF | 2/7 | 0.019996 | |
Hypertrophic cardiomyopathy (HCM) | TNF/TPM1 | 2/7 | 0.019996 | |
Dilated cardiomyopathy | TNF/TPM1 | 2/7 | 0.020091 | |
Folate biosynthesis | GCH1 | 1/7 | 0.049597 | |
Asthma | TNF | 1/7 | 0.117955 | |
African trypanosomiasis | TNF | 1/7 | 0.117955 | |
miR-93-5p | Malaria | IL6/ICAM1/THBS1 | 3/22 | 0.020688 |
Cytosolic DNA-sensing pathway | IL6/CXCL10/NFKBIA | 3/22 | 0.020688 | |
NOD-like receptor signaling pathway | NLRP3/IL6/NFKBIA | 3/22 | 0.020688 | |
RIG-I-like receptor signaling pathway | CXCL10/NFKBIA/TANK | 3/22 | 0.022958 | |
Leishmaniasis | IL1A/NFKBIA/PTGS2 | 3/22 | 0.022958 | |
Rheumatoid arthritis | IL6/ICAM1/IL1A | 3/22 | 0.036896 | |
Toll-like receptor signaling pathway | IL6/CXCL10/NFKBIA | 3/22 | 0.041751 | |
African trypanosomiasis | IL6/ICAM1 | 2/22 | 0.041751 | |
Prion diseases | IL6/IL1A | 2/22 | 0.041751 | |
Bladder cancer | CDKN1A/THBS1 | 2/22 | 0.045977 | |
Malaria | IL6/ICAM1/THBS1 | 3/22 | 0.020688 |