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Table 4 Top 10 dysregulated mRNAs in COPD patients compared with smokers without COPD

From: Bioinformatic analysis of microRNA and mRNA Regulation in peripheral blood mononuclear cells of patients with chronic obstructive pulmonary disease

Gene symbol

Gene name

Fold change

COPD/Smokers

Function

Upregulation

CD177

CD177 molecule

22.59

Leukocyte migration

MUC17

Mucin 17, cell surface associated

21.54

Extracellular matrix constituent

IL1R2

Interleukin 1 receptor, type II

10.96

Decoy receptor, inhibits the activity of IL-1

SARDH

Sarcosine dehydrogenase

9.52

Mitochondrial matrix

EGR3

Early growth response 3

6.75

Positive regulation of endothelial cell proliferation

AREG

Amphiregulin

6.16

EGF family, promote the growth of normal epithelial cells

SLC6A2

Solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2

4.70

Sodium symporter

TMEM167A

Transmembrane protein 167A

4.55

Golgi apparatus

KCNJ15

Potassium inwardly-rectifying channel, subfamily J, member 15

4.42

Potassium channel activity

FCHO1

FCH domain only 1

4.39

Clathrin-mediated endocytosis

Downregulation

IL1A

Interleukin 1, alpha

−44.69

Immune response

IL6

Interleukin 6 (interferon, beta 2)

−16.14

Pro-inflammatory and anti-inflammatory role

CXCL10

Chemokine (C-X-C motif) ligand 10

−15.08

leukocyte chemotaxis

TNF

Tumor necrosis factor

−11.79

Inflammation, cause apoptosis

CCL20

Chemokine (C-C motif) ligand 20

−7.94

Lymphocytes chemotaxis

CCL4

Chemokine (C-C motif) ligand 4

−6.19

Leukocyte chemotaxis

CCL3L3

Chemokine (C-C motif) ligand 3-like 3

−5.28

Leukocyte chemotaxis

C9orf7

Chromosome 9 open reading frame 7

−5.23

Calcium channel activity

IL1RN

Interleukin 1 receptor antagonist

−4.69

Inhibition of the activities of IL-1

RNF19B

Ring finger protein 19B

−4.17

Cytotoxic effects of natural killer (NK) cells