Table 5 Lung function and resistance parameters in the subgroup of asthma patients with pre and post methacholine challenge test

Subjects, n

11

11

Openers, n

0

4

FEV₁, %predicted

108 (91–115)

75 (67–89)

<0.0001

RV, %predicted

107 (102–118)

132 (115–162)

0.0188

TLC, %predicted

106 (95–113)

102 (89–115)

0.2014

FRC, %predicted

116 (110–120)

130 (123–140)

0.0508

RV/TLC, %

27.4 (26.4–32.5)

32.1 (27.9–48.4)

0.1289

sG_AW, 1/ kPa*sec

1.02 (0.88–1.10)

0.45 (0.38–0.51)

0.0010

sG_0.5 , 1/ kPa*sec

1.28 (1.24–1.34)

0.63 (0.57–0.69)

0.0010

Roundness

0.08 (0.02–0.09)

0.13 (0.12–0.27)

0.0029

Area of Loop

0.14 (0.02–0.18)

0.14 (0.13–0.19)

0.1678

Asynchrony, msec

20 (0–20)

20 (20–50)

0.1339

Point X, ml

−14 (−27–1)

−115 (−172–3)

0.0137

Point Y, ml/sec

−158 (−188–73)

−258 (−399–−42)

0.2447

b ₀

6.04 (4.68–7.03)

2.03 (1.67–4.11)

0.0049

b ₁

−7.72 (−11.14–−5.20)

−2.37 (−4.45–0.06)

0.0105

b ₂

2.92 (0.87–4.15)

0.91 (−0.88–2.09)

0.1242

SSG, 1/sec

5.00 (4.16–5.89)

2.13 (1.41–2.90)

0.0020

Pole1

0.95 (0.86–0.97)

0.90 (0.57–0.94)

0.3203

Pole2

0.85 (0.16–0.95)

0.71 (0.45–0.91)

0.8984