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Fig. 2 | Respiratory Research

Fig. 2

From: The cellular kinetics of lung alveolar epithelial cells and its relationship with lung tissue repair after acute lung injury

Fig. 2

a The immunofluorescence of proliferated AEC2 cells after acute lung injury. Dual immunostaining (arrowhead) for proSPC (red) and PCNA (green) was used to monitor AEC2s proliferation in alveolar after ALI. Sham D1-D7: day 1 to day 7 post sham operation. D1-D7: day 1 to day 7 post acute lung injury. SU D1-D7: day 1 to day 7 post SU11274 treated. Scale bar = 100 μm. b The ALI milieu influenced the proliferation of AEC2s. The 3rd day after ALI’s lung tissue homogenate promotes the proliferation of AEC2s significantly, *P = 0.008 (Normal: co-cultured with normal rat LTH; D3: co-cultured with the 3rd day after ALI’s LTH; D7: co-cultured with the 7th day after ALI’s LTH). c The milieu of acute lung injury accelerates AEC2 cell cycle. The 3rd day after ALI’s lung tissue accelerates AEC2 cell cycle significantly (*P = 0.028). d Cellular kinetics of alveolar epithelial cells after acute lung injury. AEC2 numbers per high power field (HPF, 0.018 mm2) (left), proliferated AEC2s per HPF (middle) and the percentage of AEC2s (%) were indicated (*P = 0.009, **P =0.008 for the association of sham group vs. ALI group; # P = 0.031, ## P =0.009 for the association of ALI group vs. SU11274 treated group)

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