Skip to main content
Fig. 5 | Respiratory Research

Fig. 5

From: Pulmonary hypertension and vascular remodeling in mice exposed to crystalline silica

Fig. 5

Abnormal endothelial and smooth muscle remodeling in the pulmonary vasculature of silica-treated mice. a, Lung sections (5 μm thick) were stained with antibodies specific for endothelium-specific von Willebrand Factor vWF (red) and α-smooth muscle actin (green). Nuclei were stained using DAPI (blue). Images were taken using 40× objective. Panel a-c: representative images of pulmonary arteries from control mice. Panel d-i: images of pulmonary arteries with different vascular abnormalities: increased accumulation of inflammatory cells around vessel (e), intimal obliteration and/or luminal occlusion by vWF-positive cells (f and h), neointimal proliferation (g and i). Bar = 100 μm. b, Quantitative analysis of medial wall thickness in pulmonary arteries. *p < 0.05 when compared to control lung, One Way ANOVA with Holm-Sidak post test

Back to article page