Fig. 1
From: Pulmonary hypertension and vascular remodeling in mice exposed to crystalline silica
Weight loss and silicotic nodules in mice treated with crystalline silica. C57BL6 male mice were intratracheally injected with different amount of crystalline silica suspension. Mice were sacrificed 28 days later. a, Silica-induced body weight changes in mice were measured at 2, 4, 7, 14, 21 and 28 days following silica administration. Mice receiving higher doses of silica showed more weight loss. Results are expressed as the mean of five mice +/− SD. b, Morphologic evidence of silica-induced lung injury. Representative images of lung from control and silica-treated mice. Arrows indicate granulomatous lesions. c, Quantitative analysis of granulomatosis in lung of silica-treated mice. *p < 0.05 when compared between treatments, One Way ANOVA with Holm-Sidak post test