Table 2 Lung damage score

Light microscopy

Perivascular edema [0–16]

1.5 [1.0–2.0]

1.0 [0.0–2.0]

6.0 [4.5–6.0]*

2.5 [2.0–3.75]#, ‡

Septal neutrophils [0–16]

0.0 [0.0–0.0]

0.0 [0.0–0.0]

5.0 [3.3–6.0]*

2.0 [1.0–4.0]#, ‡

Necrotizing vasculitis [0–16]

1.5 [0.0–2.0]

1.0 [1.0–1.0]

6.0 [6.0–6.0]*

3.0 [2.0–5.5]#, ‡

Total lung damage score [0–48]

2.5 [2.0–3.8]

2.0 [1.0–3.0]

16 [15–18]*

8.0 [5.5–11.3]#, ‡

Transmission electron microscopy

Type 2 epithelial cell damage [0–16]

3 [2–3]

2 [1–2]

6 [4–9]

5 [5–6]

Alveolar capillary membrane damage [0–16]

2 [2–3]

1 [1–2]

9 [4–12]*

5 [5–5]

Organelle injury [0–16]

2 [2–3]

1 [1–2]

6 [6–9]**

6 [4–6]

Total ultrastructural damage score [0–48]

7 [6–9]

5 [3–5]

24 [14–27]***

16 [14–17]##, ‡