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Table 1 Respiratory and blood gas-exchange parameters at Baseline and End

From: Variable ventilation improves pulmonary function and reduces lung damage without increasing bacterial translocation in a rat model of experimental pneumonia

  

SAL

PA

Parameter

 

VCV

VV

VCV

VV

Mean VT (mL/kg)

Baseline

5.8 ± 0.3

6.0 ± 0.1

6.0 ± 0.3

5.9 ± 0.4

End

5.9 ± 0.6

6.2 ± 0.3

6.0 ± 0.3

6.2 ± 0.4

CV of VT (%)

Baseline

2.5 ± 0.8

2.3 ± 0.4

1.9 ± 0.9

1.9 ± 0.8

End

1.7 ± 1.0

26.5 ± 1.8****

1.7 ± 0.8

26.6 ± 1.2 ####

E,L (cmH2O/mL)

Baseline

3.6 ± 0.5

4.2 ± 0.9

3.9 ± 0.6

4.6 ± 0.7

End

4.1 ± 0.5

2.5 ± 0.3****

3.8 ± 0.5

2.7 ± 0.2 ##

R,L (cmH2O/mL/s)

Baseline

0.19 ± 0.03

0.18 ± 0.03

0.30 ± 0.07**

0.31 ± 0.10

End

0.19 ± 003

0.16 ± 0.01

0.25 ± 0.07

0.27 ± 0.10

pHa

Baseline

7.4 ± 0.1

7.4 ± 0.0

7.3 ± 0.1

7.3 ± 0.1

End

7.4 ± 0.1

7.4 ± 0.0

7.4 ± 0.1

7.4 ± 0.0

PaO2/FiO2

Baseline

372 ± 126

311 ± 83

260 ± 59

285 ± 80

End

292 ± 78

449 ± 50**

302 ± 117

454 ± 59##

PaCO2 (mmHg)

Baseline

40.2 ± 8.0

39.6 ± 6.0

40.2 ± 4.9

42.9 ± 11.1

End

36.4 ± 10.1

33.9 ± 7.3

37.2 ± 4.8

36.5 ± 8.8

HCO3 (mEq/L)

Baseline

23.7 ± 3.1

24.0 ± 2.5

20.8 ± 3.2

20.8 ± 3.2

End

18.9 ± 4.4

20.0 ± 4.4

21.5 ± 2.6

21.5 ± 2.6

MAP (mmHg)

Baseline

109 ± 24

99 ± 12

96 ± 34

110 ± 27

End

99 ± 15

110 ± 22

97 ± 28

112 ± 28

  1. Values are mean ± standard deviation (SD) of 8 animals in each group
  2. Abbreviations: SAL-VCV rats administered intratracheal saline and ventilated with volume-controlled ventilation, SAL-VV rats administered intratracheal saline and ventilated with variable ventilation, PA-VCV rats administered intratracheal Pseudomonas aeruginosa and ventilated with volume-controlled ventilation, PA-VV rats administered intratracheal Pseudomonas aeruginosa and ventilated with variable ventilation, V T tidal volume, CV coefficient of variation, E, L dynamic lung elastance, R, L lung resistance, pHa arterial pH, PaCO 2 arterial carbon dioxide partial pressure, PaO 2 /FiO 2 arterial oxygen partial pressure divided by fraction of oxygen inspired, HCO 3 bicarbonate, MAP mean arterial pressure
  3. Comparisons were performed using two-way repeated measures ANOVA followed by the Holm-Šídák post-hoc test (p < 0.05). **p < 0.005; ****p < 0.0001 vs SAL-VCV. ##p < 0.01; ####p < 0.0001 vs PA-VCV