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Fig. 3 | Respiratory Research

Fig. 3

From: Variable ventilation improves pulmonary function and reduces lung damage without increasing bacterial translocation in a rat model of experimental pneumonia

Fig. 3

Expression of biological markers. Real-time polymerase chain reaction analysis of biological markers associated with inflammation (IL-6 and CINC-1), alveolar overdistension (amphiregulin), endothelial cell damage (angiopoietin [Ang]-2), and epithelial cell mechanotransduction (surfactant protein [SP]-D). Relative gene expression was calculated as the ratio of average gene expression levels compared with the reference gene (36B4) and expressed as fold change relative to non-ventilated (NV) animals with pneumonia (PA). SAL-VCV: rats administered intratracheal saline and ventilated with volume-controlled ventilation; SAL-VV = rats administered intratracheal saline and ventilated with variable ventilation; PA-VCV = rats administered intratracheal Pseudomonas aeruginosa and ventilated with volume-controlled ventilation; PA-VV = rats administered intratracheal Pseudomonas aeruginosa and ventilated with variable ventilation. Values represent medians and whiskers represent the 10–90 percentile range of 8 animals in each group. Kruskal–Wallis test followed by Dunn’s test for comparisons among groups (p < 0.05)

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Respiratory Research

ISSN: 1465-993X

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