Fig. 3

Gene networks and molecular drivers underlying symptomatic host responses to infection. Gene expression patterns were profiled in blood from adult volunteers after experimental infection with RSV, RV or IAV [3]. Differentially expressed were identified between symptomatic versus asymptomatic subjects for each virus, resulting in 934 differentially expressed genes for IAV (adjusted p-value < 0.05), 173 genes for RV (adj p-value < 0.05), and 130 genes for RSV (adj p-value < 0.1). a/c/e; Network wiring diagrams were constructed utilizing experimentally supported findings from prior studies (Ingenuity Systems KnowledgeBase) [50]. Genes coloured red were upregulated and those coloured green were downregulated. b/d/f; Upstream regulator analysis was employed to identify the molecular drivers of the response [51]. The negative log p-value was shaded red to indicate pathway activation, and blue indicates inhibition