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Table 3 Test-duration and provocation-doses of methacholine (mg) needed to achieve the different provocation-dose levels

From: Diagnostic accuracy of methacholine challenge tests assessing airway hyperreactivity in asthmatic patients - a multifunctional approach

Comparison of average test-duration until different PD-levels reached

 

Number

Mean

SD

Lower 95%CL

Upper 95%CL

PD40 sGeff

484

14:45

05:54

14:15

15:14

PD20 FEV1

484

17:46

05:16

17:18

18:14

PD20 FEF50

484

16:17

05.36

15:47

16:47

Test-duration: sGeff < FEV1; sGeff < FEF50; FEF50 < FEV1 (p<0.001)

Provocation-doses of methacholine (mg) needed to reach the different PD levels

PD40 sGeff

AHR

409

.495

.491

.447

.543

No AHR

75

2.185

.059

2.17

2.197

PD20 FEV1

AHR

176

.739

.615

.647

.830

No AHR

243

2.189

.044

2.183

2.194

PD-level not reached

65

.873

.450

.761

.985

PD20 FEF50

AHR

307

.625

.588

.559

.691

No AHR

146

2.188

.046

2.180

2.195

PD-level not reached

31

.936

.496

.754

1.117

Comparison between the 3 test procedures assessed by summary independent sample t-test

 

mean diff.

SE

t

Significance

PD40 sGeff versus PD20 FEV1

.244

.048

5.088

p<.000

PD40 sGeff versus PD20 FEF50

.130

.040

3.223

p=.001

PD20 FEV1 versus PD20 FEF50

.114

.056

2.011

p=.045