Table 2 Measures of MCH-challenge procedures computed for response characteristics of sGeff, FEV1 and FEF50
PD-40sGeff | PD-45sGeff | PD-50sGeff | PD-20FEV1 | PD-20FEF50 | |
|---|---|---|---|---|---|
N | 484 | 484 | 484 | 484 | 484 |
PD-level not reached (%) | 0 (0) | 6 (1.2) | 16 (3.3) | 44 (9.1) | 31 (6.4) |
Diagnostic accuracy differentiating AHR from non-AHR in all patients but excluding patients not having reached PD-level | |||||
n (%) | 484 (100) | 478 (98.8) | 468 (96.7) | 440 (90.9) | 453 (93.6) |
Prevalence | 69.6% | 69.6% | 69.6% | 69.6% | 69.6% |
Sensitivity | 93.2% | 89.3% | 82.8% | 54.9% | 71.5% |
Specificity | 35.4% | 44.2% | 52.4% | 85.0% | 55.1% |
PPV | 76.8% | 78.6% | 79.9% | 89.4% | 78.5% |
NPV | 69.3% | 64.4% | 57.0% | 45.1% | 45.8% |
Diag. Odds Ratio (DOR) [33] | 7.473 | 6.628 | 5.291 | 6.915 | 3.081 |
95% CI of DOR | 4.347–12.847 | 4.123–10.655 | 3.443–8.133 | 4.189–11.417 | 2.061–4.605 |
pos. LR | 1.443 | 1.600 | 1.739 | 3.660 | 1.592 |
neg. LR | 0.192 | 0.242 | 0.328 | 0.531 | 0.517 |
Diagnostic effectiveness | 0.756 | 0.756 | 0.736 | 0.641 | 0.665 |
Cumulative percent-response in all patients (asthmatics and non-asthmatic subjects) at each provocation level n/n (%) | |||||
1st PD level (%) | 161/484 (42.4) | 126/484 (26.0) | 94/484 (19.4) | 94/484 (9.7) | 99/484 (20.5) |
2nd PD level (%) | 362/484 (74.8) | 326/484 (67.4) | 296/484 (61.2) | 217/484 (44.8) | 280/484 (57.9) |
3rd PD level (%) | 415/484 (85.7) | 395/484 (81.6) | 376/484 (77.7) | 270/484 (55.8) | 344/484 (71.1) |
No AHR detected | 104/484 (21.5) | 132/484 (27.3) | 164/484 (33.9) | 302/484 (62.4) | 206/484 (42.6) |