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Table 1 Subject’s characteristics (N = 484; 199 males (41.1%, 285 females (58.9%), age-range (9.1–87.1 years

From: Diagnostic accuracy of methacholine challenge tests assessing airway hyperreactivity in asthmatic patients - a multifunctional approach

 

Asthmatic patients n = 337

Non-asthmatic subjects

n = 147

Upper airway Cough syndrome (UACS)

Gastrooesophageal reflux disease (GERD)

Chronic Cough (smoking, post-infection, unknown)

Symptom complex (dyspnea, chest tightness, hyperventilation, somatisation)

All non-asthmatic subjects

n (% distribution)

337 (69.6)

55 (37.4)

40 (27.2)

30 (20.4)

22 (15.0)

147 (30.4)

Gender male/female (% distribution)

129/208 (38.3/61.7)

26/29 (47.3/52.7)

18/22 (45.0/55.0)

18/12 (60.0/40.0)

8/14 (36.4/63.6)

70/77 (47.6/52.4)

Age in years (mean ± SD) (age-range)

41.3 ± 18.9 (9.1-87.1)

47.0 ± 17.0 (10.6-80.5)

55.0 ± 15.3 (26.3-83.1)

55.2 ± 17.3 (15.9-82.8)

40.4 ± 18.4 (13.9-72.9)

49.9 ± 17.5 (10.6-82.8)

Functional Characteristics of plethysmographic measurements assessed by z-scores n (% within group)

Normal LF

280 (83.1)

42 (76.4)

31 (77.5)

26 (86.7)

19 (86.4)

118 (80.3)

Pulmonary hyperinflation (PHI)

28 (8.3)

12 (21.8)

7 (17.5)

2 (6.7)

3 (13.6)

24 (16.3)

Bronchial obstruction (O)

26 (7.7)

1 (1.8)

2 (5.0)

0

0

3 (2.0)

PHI and O

3 (0.9)

0

0

2 (6.7)

0

2 (1.4)

Functional Characteristics of spirometric measurements assessed by z-scores by plethysmography n (%)

Normal F-V curve

305 (90.5)

50 (36.9)

40 (100)

29 (96.7)

19 (86.4)

138 (93.9)

Flow limitation (FL)

26 (7.7)

5 (9.1)

0

1 (3.3)

3 (13.6)

9 (6.1)

SAD

1 (0.3)

0

0

0

0

0 (0)

FL & SAD

5 (1.53)

0

0

0

0

0

  1. LF lung function, PHI pulmonary hyperinflation (FRCpleth > 1.645 SD), O airway obstruction (sGeff < 1.645 SD), F-V flow-volume, FL flow-limitation (FEV1 < −1.645 SD), SAD small airway dysfunction (FEF50 < − 1.645 SD)