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Fig. 4 | Respiratory Research

Fig. 4

From: Disharmony between wake- and respiration-promoting activities: effects of modafinil on ventilatory control in rodents

Fig. 4

Minute ventilation (\( {\overset{.}{\mathrm{V}}}_{\mathrm{E}} \)), tidal volume (VT), respiratory rate (RR), and coefficient of variations of VT and total respiratory cycle in the three pharmacological conditions (DMSO and 100 and 200 mg/kg of the modafinil) in response to the four air conditions (baseline room air, 5% CO2, 10% O2, and recovery room air). Significant interactions between conditions were revealed by the two-way repeated measures ANOVA for \( {\overset{.}{\mathrm{V}}}_{\mathrm{E}} \) (F(6, 48) = 5.54, ε GG = 0.21, P < 0.05), VT (F(6, 48) = 3.47, ε GG = 0.39, P < 0.05), and the coefficient of variation of VT (F(6, 48) = 2.96, P < 0.05). For RR, the interaction was marginally short of conventional level of statistical significance (F(6, 48) = 2.93, ε GG = 0.38, P = 0.07). Post hoc Bonferroni test revealed some significant differences (*). For the coefficient of variation of total respiratory cycle, either the interaction between conditions or the main effect regarding pharmacological condition was not significant (F(6, 48) = 0.85, P = 0.85, and F(2, 16) = 2.62, P = 0.10, respectively). DMSO: dimethyl sulfoxide

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