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Table 3 Initial physiologic and radiologic characteristics according to total GAP score

From: Predicting survival of patients with idiopathic pulmonary fibrosis using GAP score: a nationwide cohort study

Variable

Total GAP score (n = 1,228)

p-value

1 (n = 150)

2 (n = 208)

3 (n = 376)

4 (n = 317)

5 (n = 138)

6 (n = 39)

Pulmonary function test

 FVC (%)

85.6 ± 13.4

81.9 ± 17.4

81.3 ± 17.2

71.4 ± 15.7

63.2 ± 15.1

55.5 ± 12.9

<0.001a

 FEV1 (%)

93.1 ± 15.0

91.4 ± 21.2

92.5 ± 19.5

82.9 ± 16.8

74.4 ± 16.2

64.9 ± 14.9

<0.001a

 TLC (%)

90.8 ± 19.7

84.8 ± 19.7

87.2 ± 18.5

80.2 ± 18.6

72.0 ± 15.6

67.1 ± 23.9

<0.001a

 DLCO (%)

75.8 ± 15.8

67.4 ± 17.1

67.1 ± 21.3

59.2 ± 19.9

41.7 ± 13.6

31.9 ± 11.1

<0.001a

Resting PaO2 mm Hg

90.5 ± 21.2

85.8 ± 19.6

82.5 ± 22.3

78.6 ± 18.7

74.5 ± 21.5

69.5 ± 13.7

<0.001a

Resting PaCO2 mm Hg

39.3 ± 8.2

39.2 ± 6.5

37.4 ± 7.8

36.5 ± 6.2

35.1 ± 6.9

36.7 ± 6.4

<0.001a

Radiologic finding

 Reticular pattern

108 (75.5)

144 (73.5)

214 (60.5)

185 (65.4)

82 (65.6)

22 (62.9)

0.008

 Honeycombing change

105 (77.2)

141 (71.9)

282 (78.6)

241 (81.4)

110 (84.0)

31 (81.6)

0.101

 Ground glass opacities

98 (68.5)

132 (68.4)

206 (58.9)

155 (58.5)

67 (56.3)

22 (68.8)

0.052

 Nodular lesions

26 (20.3)

37 (19.9)

85 (25.5)

58 (23.6)

23 (21.9)

8 (25.8)

0.702

  1. Note: Values in parentheses are percentages
  2. GAP gender, age, and 2 lung physiology variables (FVC and DLCO), FVC forced vital capacity, % pred percentage of the predicted value, FEV 1 forced expiratory volume, TLC total lung capacity, DL CO diffusing capacity of the lung for carbon monoxide, PaO 2 arterial oxygen tension, PaCO 2 arterial carbon dioxide tension
  3. athe following post hoc comparisons were significant at the p = 0.05 level; all other comparisons were non-significant: Score 1 group versus Score 4, 5, 6 groups, Score 2 group versus Score 4, 5, 6 groups, Score 3 group versus Score 4, 5, 6 groups and Score 4 group versus Score 5, 6 groups (FVC (%)); Score 1 group versus Score 4, 5, 6 groups, Score 2 group versus Score 4, 5, 6 groups, Score 3 group versus Score 4, 5, 6 groups and Score 4 group versus Score 5, 6 groups (FEV1 (%)); Score 1 group versus Score 4, 5, 6 groups, Score 2 group versus Score 5, 6 groups, Score 3 group versus Score 4, 5, 6 groups, and Score 4 group versus Score 5, 6 groups (TLC (%)); Score 1 group versus Score 2, 3, 4, 5, 6 groups, Score 2 group versus Score 4, 5, 6 groups, Score 3 group versus Score 4, 5, 6 groups, and Score 4 versus Score 5,6 groups (DLCO (%)); Score 1 group versus Score 3, 4, 5, 6 groups, Score 2 group versus Score 4, 5, 6 groups, and Score 3 group versus Score 5, 6 groups (Resting PaO2); Score 1 group versus Score 4, 5 groups and Score 2 group versus Score 4, 5 groups (Resting PaCO2)