Skip to main content
Fig. 6 | Respiratory Research

Fig. 6

From: N-methyl-D-aspartate receptor activation mediates lung fibroblast proliferation and differentiation in hyperoxia-induced chronic lung disease in newborn rats

Fig. 6

NMDAR activation promotes lung fibroblasts proliferation in hyperoxia exposure newborn rat. The red fluorescent cells (EdU-positive) were in the S phase of mitosis, and the blue fluorescent cells (Hoechst 33342-positive) represented all the cells. The percentage of EdU-positive cells was significantly higher in the hyperoxia group (P < 0.01) (A c vs A a, B), whereas MK-801 inhibited cells’ proliferation induced by hyperoxia (P < 0.01) (A d vs A c, B). MK-801 alone had no influence on normal cell growth. †† P < 0.05 vs. hyperoxia group, n = 6 per group; H: hyperoxia group; C: control group; M: air + MK-801 group; HM: hyperoxia + mk-801 group. Magnification × 20. **P <0.01 vs. air group

Back to article page

Respiratory Research

ISSN: 1465-993X

Contact us