Fig. 1

Levels of inflammation-related cytokines and chemokines in induced sputa of CF patients before and at least one month after induction of inhaled HMW-HA treatment (all patients were on hypertonic saline treatment throughout this period). Levels of HA in induced sputa of CF patients without inhaled HMW-HA treatment and at least one month after induction of inhaled HMW-HA treatment. Left panel depicts comparison of two separate groups of patients, on and off HMW-HA treatment, and right panel depicts HA levels in patients transitioned from HTS to HTS + HMW-HA treatment. a Levels of HA in induced sputa of CF patients before and at least one month after induction of inhaled HMW-HA treatment, divided according to initial HA levels prior to treatment initiation. b Agarose gel of HA sizes in induced sputa of CF patients before (lanes “a”) and at least one month after induction (lanes “b”) of inhaled HMW-HA treatment. Patients 1–3 had low initial HA levels, and patients 4–6 had high initial HA levels. In patients 1–3 there is apparent increase in HA, as well as shift of HA size towards larger molecular weights. In patients 4–6 there is evidence of decreased HA abundance but no apparent change in HA size