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Table 3 Discriminatory power for the prognosis of death

From: High levels of biomarkers of collagen remodeling are associated with increased mortality in COPD – results from the ECLIPSE study

 

AUC (95 % CI)

P value

Serological biomarkers

 C6M

0.724 (0.695–0.752)

-

 Pro-C6

0.722 (0.692–0.751)

-

 CRP

0.719 (0.689–0.747)

-

 C6M + Pro-C6

0.796 (0.769–0.822)

-

 C6M + CRP

0.727 (0.697–0.755)

-

 Pro-C6 + CRP

0.775 (0.746–0.802)

-

 C6M + Pro-C6 + CRP

0.791 (0.762–0.818)

-

Clinical models

 Age + BODE + Previous exacerbations

0.750 (0.721–0.778)

 

  + C3M

0.803 (0.776–0.829)

0.084

  + CRPM

0.807 (0.780–0.832)

0.044

  + C6M

0.813 (0.786–0.837)

0.038

  + Pro-C6

0.826 (0.799–0.851)

0.071

  + CRP

0.811 (0.783–0.836)

0.046

  + C6M + Pro-C6

0.867 (0.843–0.889)

0.001

  + C6M + CRP

0.817 (0.790–0.842)

0.023

  + C6M + CRPM

0.818 (0.791–0.842)

0.036

  + Pro-C6 + CRP

0.863 (0.837–0.886)

0.001

  + Pro-C6 + CRPM

0.864 (0.840–0.886)

0.003

  + C6M + Pro-C6 + CRP

0.871 (0.846–0.893)

0.0004

  + C6M + Pro-C6 + CRPM

0.871 (0.847–0.893)

0.001

  1. Shown are the single biomarkers with an area under the ROC curve (AUC) >0.700 and models with AUC >0.800. P values compare the AUC of the clinical model alone to the clinical model with added biomarker(s)