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Fig. 5 | Respiratory Research

Fig. 5

From: A HuR/TGF-β1 feedback circuit regulates airway remodeling in airway smooth muscle cells

Fig. 5

Suppression of TGF-β1 ablated HuR and Col-I expression but exogenous TGF-β1 restored HuR and Col-I expression. a Knockdown of TGF-β1 decreased ASM cells viability by CCK8 assay. b Small interfere RNA decreased TGF-β1 expression compared with control siRNA. (c) After silencing TGF-β1, HuR and Col-I were also alleviated even though under the stimulation of PDGF. de Exogenous TGF-β1 treatment increased endogenous HuR and Col-I expression.β-actin in western blotting were the internal control. Density ratio of bands in western blotting was calculated and represented as relative expression level. *P < 0.05 compared with control; # P < 0.05 control siRNA vs. TGF-β1 siRNA

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