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Table 2 Inhibition of cytokine production by dexamethasone, tofacitinib and PIK-294 in TCR-stimulated BAL cells from asthma patients and healthy subjects

From: Anti-inflammatory potential of PI3Kδ and JAK inhibitors in asthma patients

Compound Cytokine IC35 values (nM) IC50 values (nM) Mean % inhibition at 10 μM +/− SD
Healthy Asthma Healthy Asthma Healthy Asthma
Dexamethasone IFNγ 2.6 3.4 7.6 28.7 75.2 +/− 20.8 69.1 +/− 26.7
IL-13 <1.0a <1.0a 1.1 1.2 96.6 +/− 6.8 77.3 +/− 31.1
IL-17 8.7 267.8 1098 >10,000b 57.6 +/− 15.3 45.8 +/− 21.7
Tofacitinib IFNγ 56.8 56.7 135.2 141.1 96.1 +/− 2.9 94.9 +/− 7.2
IL-13 24.8 26.5 48.8 75.6 85.8 +/− 9.4 90.0 +/− 11.5
IL-17 297 1042 1321 2495 80.4 +/− 9.2 83.1 +/− 11.0
PIK-294 IFNγ 6.8 5.3 31.7 35.8 77.5 +/− 17.1 84.4 +/− 14.5
IL-13 1.3 <1.0a 19.0 31.2 87.4 +/− 9.3 93.0 +/− 5.5
IL-17 9.6 10.1 368.4 75.9 61.3 +/− 14.7 70.3 +/− 12.2
  1. Absolute IC35 and IC50 values calculated from the mean % inhibition for each drug concentration tested. aIC35 value uncalculatable as >35 % mean inhibition observed with 1.0 nM of drug; bIC50 value uncalculatable as <50 % mean inhibition observed with 10,000 nM of drug