Fig. 2
From: The genetic and epigenetic landscapes of the epithelium in asthma
Role of miRNAs in airway epithelial cells regeneration. a In healthy airway epithelial cells, miR-449 suppresses NOTCH1 mRNA and encourages differentiation of ciliated cells compared with goblet cells. miR-203 may paly essential role in epithelial cell homeostasis by suppressing p63 which is expressed in basal cells. b The level of miR-449 and miR-203 are reduced in asthmatic airway epithelial cells, which may result in increase in goblet cells and compromising epithelial cells regeneration, respectively. Solid lines and bold fonts represent strong effect and dashed lines and normal font represent weak effect