Table 4 Tregs and cytokines in CBMCs of offspring with and without childhood allergies
|  | Children without allergies (n = 202) | Children with allergies (n = 71) | P-value |
|---|---|---|---|
CD4+CD25+ FOXP3+ T cells, % in CBMCs (SEM) | |||
 U | 1.91 (0.67) | 1.17 (0.61) | 0.12 |
 LPA | 2.15 (0.73) | 1.45 (0.54) | 0.08 |
 PPG | 2.44 (0.63) | 1.57 (0.49) | 0.01 |
FOXP3 gene expression, fold difference (IQR) | |||
 LPA | 3.14 (1.60–5.25) | 1.41 (0.70–2.64) | 0.01 |
 PPG | 4.03 (1.32–6.02) | 1.98 (1.25–4.14) | 0.02 |
GITR gene expression, fold difference (IQR) | |||
 LPA | 2.14 (1.0–5.14) | 2.79 (0.96–10.44) | 0.12 |
 PPG | 2.42 (0.99–6.96) | 3.67 (0.95–8.61) | 0.44 |
LAG3 gene expression, fold difference (IQR) | |||
 LPA | 2.14 (0.61–4.65) | 1.19 (0.68–3.36) | 0.51 |
 PPG | 2.0 (0.54–3.73) | 2.22 (0.63–4.74) | 0.61 |
IL-10 production, pg/ml (IQR) | |||
 U | 0.10 (0.01–0.26) | 0.15 (0.01–0.21) | 0.35 |
 LPA | 177.93 (110.74–229.50) | 135.28 (88.14–192.87) | 0.09 |
 PPG | 1078.74 (730.84–1518.49) | 830.74 (623.0–1038.23) | 0.016 |
IL-13 production, pg/ml (IQR) | |||
 U | 0.16 (0.01–0.37) | 0.21 (0.01–0.35) | 0.63 |
 LPA | 4.5 (1.65–11.83) | 5.07 (1.70–13.26) | 0.80 |
 PPG | 31.70 (12.88–50.53) | 30.59 (11.90–61.45) | 0.53 |
IFN-γ production, pg/ml (IQR) | |||
 U | 1.02 (0.01–1.99) | 1.66 (0.45–2.51) | 0.09 |
 LPA | 5.08 (2.81–16.86) | 4.91 (2.82–7.72) | 0.55 |
 PPG | 13.15 (6.12–30.33) | 10.22 (4.96–26.50) | 0.53 |
IL-17 production, pg/ml (IQR) | |||
 U | 0.01 (0.01–0.47) | 0.01 (0.01–0.43) | 0.96 |
 LPA | 1.71 (0.19–4.39) | 0.84 (0.01–2.80) | 0.12 |
 PPG | 2.94 (1.28–11.41) | 2.34 (0.74–6.48) | 0.18 |