Table 3 Tregs and cytokines in CBMCs of offspring with and without maternal allergy
|  | Maternal non-allergy (n = 222) | Maternal allergy (n = 90) | P-value |
|---|---|---|---|
CD4+CD25+ FOXP3+ T cells, % in CBMCs (SEM) | |||
 U | 1.78 (0.71) | 1.57 (0.76) | 0.12 |
 LPA | 2.05 (0.75) | 1.81 (0.76) | 0.08 |
 PPG | 2.33 (0.69) | 1.99 (0.68) | 0.01 |
FOXP3 gene expression, fold difference (IQR) | |||
 LPA | 3.14 (1.79–5.24) | 2.50 (0.83–4.88) | 0.021 |
 PPG | 3.36 (1.32–4.92) | 2.69 (1.22–5.86) | 0.024 |
GITR gene expression, fold difference (IQR) | |||
 LPA | 2.83 (1.53–6.24) | 1.50 (0.95–3.03) | 0.16 |
 PPG | 3.93 (1.87–8.46) | 2.46 (0.95–5.89) | 0.15 |
LAG3 gene expression, fold difference (IQR) | |||
 LPA | 2.83 (1.39–6.45) | 1.53 (0.90–3.03) | 0.12 |
 PPG | 2.93 (1.88–5.66) | 2.00 (0.85–2.95) | 0.028 |
IL-10 production, pg/ml (IQR) | |||
 U | 0.19 (0.01–0.27) | 0.035 (0.01–0.23) | 0.81 |
 LPA | 173.71 (109.24–198.26) | 135.16 (91.37–241.89) | 0.43 |
 PPG | 1104.47 (806.43–1519.56) | 868.44 (603.76–1153.45) | 0.006 |
IL-13 production, pg/ml (IQR) | |||
 U | 0.16 (0.01–0.33) | 0.13 (0.01–0.36) | 0.52 |
 LPA | 3.81 (1.45–7.80) | 5.87 (1.48–13.21) | 0.06 |
 PPG | 25.44 (12.41–53.98) | 33.38 (13.14–61.53) | 0.021 |
IFN-γ production, pg/ml (IQR) | |||
 U | 1.02 (0.01–1.99) | 1.02 (0.45–1.99) | 0.49 |
 LPA | 5.52 (3.47–17.64) | 3.95 (1.64–9.66) | 0.04 |
 PPG | 14.28 (6.57–33.42) | 8.66 (5.02–18.96) | 0.047 |
IL-17 production, pg/ml (IQR) | |||
 U | 0.09 (0.01–0.47) | 0.12 (0.01–0.67) | 0.38 |
 LPA | 2.39 (0.24–4.39) | 2.26 (0.81–4.10) | 0.86 |
 PPG | 2.7 (1.65–10.99) | 4.03 (2.74–19.25) | 0.049 |