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Fig. 8 | Respiratory Research

Fig. 8

From: Human primary airway epithelial cells isolated from active smokers have epigenetically impaired antiviral responses

Fig. 8

Demethylation restored IAV induced cytokine IP-10 (a) and IFN λ2/3 (b) protein expression in supernatants of HBEC isolated from smokers. HBEC were treated with fresh 5 μM and 7.5 μM 5-Aza each day for 3 days before IAV infection. After infection of the cells with IAV at an MOI of 1 for 24 h, supernatants were collected and cytokine expression was assessed by ELISA. Data were expressed as the means ± SEM from three separate experiments from different donors. * denotes significant difference compared to data from the IAV treated cells from nonsmokers, P < 0.05. # denotes no significant difference compared to data from the IAV infected cells from nonsmokers (NS + IAV)

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Respiratory Research

ISSN: 1465-993X

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