Serum extracellular vesicular miR-21-5p is a predictor of the prognosis in idiopathic pulmonary fibrosis

Respiratory Research

Table 7 Characteristics of the two groups into which IPF patients were divided according to the median of the normalized levels of serum EV miR-21-5p

	Normalized miR-21-5p (copies/SI)		P value
	<2.1	≥2.1
	(n = 20)	(n = 21)
Age, yr	71 (65–77)	75 (71–81)	0.15
Sex, male, n (%)	19 (95)	13 (61)	0.02
Smoking history
Yes, n (%)	18 (90)	16 (76)	0.4
Baseline VC (%)	78 (69–104)	81 (62–91)	0.48
Emphysematous lesion detected by CT, n (%)	2 (10)	2 (10)	0.96
KL-6	645 (540–982)	1040 (706–1921)	0.04
SP-D	211 (141–277)	202 (140–320)	0.77
LDH	207 (183–215)	227 (177–280)	0.18

The data are expressed as n (%) or median (IQR). The differences in age, % VC, or other serum markers between the two groups were analysed by the Mann-Whitney U test. The comparison of gender, smoking history and emphysema between the two groups was analysed using the Fisher exact test
Bold represents p < 0.05
VC vital capacity, KL-6 Krebs von den Lungen-6, SP-D surfactant protein D

ISSN: 1465-993X