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Table 1 The fold-changes of the serum EV microRNAs that had been reported to be associated with the pathogenesis of lung fibrosis in the bleomycin-induced lung fibrosis model compared with the non-treated controls

From: Serum extracellular vesicular miR-21-5p is a predictor of the prognosis in idiopathic pulmonary fibrosis

Name

Day 7

Day 14

Day 28

Reference

Fold change

q value

Fold change

q value

Fold change

q value

Upregulated microRNAs in lung fibrosis

 miR-21-5p

9.29*

0.003

5.77*

0.036

7.97*

0.001

[19, 37–39]

 miR-96-5p

ND

 

ND

 

ND

 

[42]

 miR-145a-5p

0.68

0.715

2.35

0.647

0.81

0.554

[43]

 miR-155-5p

4.28*

0.009

3.26*

0.039

6.37*

0.001

[44]

 miR-195a-5p

1.79

0.314

1.40

0.976

1.13

0.828

[45]

Downregulated microRNAs in lung fibrosis

 miR-17-3p

12.33*

0.022

2.54

0.705

2.12

0.878

[46]

 miR-17-5p

0.91

0.724

1.81

0.713

0.55

0.465

[46]

 miR-18a-5p

1.90

0.375

2.59

0.622

1.46

0.920

[46]

 miR-19a-3p

4.10*

0.008

2.51

0.059

1.99

0.199

[46]

 miR-20a-5p

1.40

0.508

1.91

0.804

0.56

0.498

[46]

 miR-29a-3p

1.81

0.333

1.55

0.805

0.52

0.451

[47]

 miR-30d-5p

1.61

0.359

1.74

0.701

1.33

0.922

[48, 49]

 miR-92a-3p

0.71

0.918

1.68

0.701

1.41

0.855

[46, 48]

 miR-200a-3p

4.23

0.085

1.91

0.717

4.58

0.388

[50]

 miR-200b-3p

4.29

0.159

1.20

0.515

2.55

0.546

[50]

 miR-200c-3pa

3.41

0.112

3.03

0.797

2.55

0.554

[19, 50]

  1. ND not detected (Ct > 35)
  2. *q value < 0.05 compared with non-treated control
  3. amicroRNAs that had Ct > 30 in either group, which indicated that the expression levels were relatively low and could cause greater variations in the fold-change results