Sputum cells | Placebo (n = 21) | Simvastatin (n = 21) | P value | Treatment difference, simvastatin minus placebo (95 % CI) | Effects by order P value |
---|---|---|---|---|---|
Δ sputum ADA mRNA (fold change) (n = 13) | 0.3 ± 1.4 | 2.8 ± 3.1 | 0.001 | 2.8 (1.3 to 4.2) | 0.7 |
Δ sputum ADA (U/L) | −1.5 ± 9.4 | 22.0 ± 18.4 | <0.001 | 23.3 (15.0 to 31.6) | 0.19 |
Δ sputum osteopontin mRNA (fold change) (n = 13) | 1.6 ± 2.5 | −0.6 ± 0.3 | 0.012 | −2.4 (−4.1 to −0.6) | 0.69 |
Δ sputum osteopontin (ng/mL) | 0.15 ± 0.6 | −0.71 ± 0.6 | <0.001 | −0.85 (− 1.2 to −0.5) | 0.92 |
Δ sputum inosine (nmol) | −0.1 ± 0.1 | 0.3 ± 0.2 | <0.001 | 0.37 (0.29 to 0.43) | 0.054 |
Δ sputum CD73 mRNA (fold change) (n = 13) | 0.7 ± 1.3 | −0.2 ± 0.6 | 0.01 | −0.91 (−0.37 to −1.5) | 0.99 |
Δ sputum CD73 (%) | 0.58 ± 8.7 | −7.5 ± 13.6 | 0.006 | −8.3 (−13.8 to −2.7) | 0.92 |
Δ sputum IL-13 (pg/mL) | −2.0 ± 9.9 | −16.9 ± 8.3 | <0.001 | −15.0 (−20.4 to −9.6) | 0.69 |