Table 2 Baseline induced sputum cytology and inflammatory marker levels and before-after each treatment

 ADA mRNA

 (fold change) (n = 13)

1.03 ± 0.06

1.04

[1.0-1.05]

1.01

[0.7-1.4]

0.84

1.0

[1.0-1.0]

2.7

[2.3-2.9]

0.0002

 ADA (U/L)

29.5 ± 8.9

29.8 ± 10.4

28.3 ± 9.4

0.47

28.7 ± 10.7

50.6 ± 23.7

<0.001

 OPN mRNA

 (fold change) (n = 13)

1.0 ± 0.0

1.0

[1.0-1.0]

2.2

[0.8-4.2]

0.026

1.0

[1.0-1.0]

0.4

[0.2-0.6]

<0.001

 OPN (ng/mL)

1.5 ± 0.6

1.6 ± 0.7

1.8 ± 0.9

0.25

1.7 ± 0.6

0.9 ± 0.5

<0.001

 CD73 mRNA

 (fold change) (n = 13)

1.0 ± 0.02

1.0

[1.0-1.01]

1.05

[0.97-2.3]

0.065

1.0

[1.0-1.01]

0.8

[0.2-1.02]

0.057

 Total CD73 (%)

12.4 ± 9.1

9.6

[3.5-12.6]

4.8

[1.5-13.6]

0.76

12.3

[5.0-25.1]

5.7

[2.5-9.2]

0.0071

 Inosine (nmol)

0.57 ± 0.1

0.59 ± 0.1

0.52 ± 0.1

0.0034

0.5 ± 0.2

0.8 ± 0.1

<0.001

 IL-13 (pg/ml)

26.3 ± 7.9

25.4 ± 8.9

23.4 ± 11.7

0.36

27.8 ± 6.6

10.9 ± 8.2

<0.001