Skip to main content
Fig. 3 | Respiratory Research

Fig. 3

From: Simvastatin up-regulates adenosine deaminase and suppresses osteopontin expression in COPD patients through an IL-13-dependent mechanism

Fig. 3

a Inhibitory effects of simvastatin on IL-13 mRNA expression in CSE-treated MDM from COPD patients in a dose-dependent manner. The inhibitory effects of simvastatin (2 ng/ml) on OPN mRNA expression (b) and protein concentration (c), and STAT6 phosphorylation (f). The enhancing effects of simvastatin (2 ng/ml) on ADA mRNA expression (d) and protein concentration (e). MDM from healthy subjects were used to demonstrate the effect of CSE and simvastatin on IL-13, OPN, and ADA transcription (g, h, i, respectively). This also illustrates the reversal of the above effects of simvastatin by the addition of exogenous human recombinant IL-13. Results are expressed as the means (±SD) values of six independent experiments from 6 COPD patients and 4 healthy subjects. *, p < 0.05 and **, p < 0.001 vs control

Back to article page

Respiratory Research

ISSN: 1465-993X

Contact us