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Table 1 Characteristics of IPAH patients and Control group

From: Activation of the nicotinamide N-methyltransferase (NNMT)-1-methylnicotinamide (MNA) pathway in pulmonary hypertension

Parameter (units) IPAH patients, n=10 Controls, n=8 p
age (years) 41 (37-50) 54 (37-60) 0.24
sex (M) 3 (30 %) 3 (38 %) 0.87
NT-proBNP (pg/ml) 1204 (837-2327) 63 (28.5-135,4) 0.0002
ET-1 (ng/ml) 2.54 (2.06-2.79) 0.63 (0.49-0.86) 0.0002
6MWD (m) 397.5 (345-420) 460 (420-630) 0.02
Hb (g/dl) 15.4 (14.4-16.0) 13.3 (11.8-14.4) 0.01
PAP mean (mmHg) 52 (43-56) 12 (10-14.5) 0.0004
PWP (mmHg) 6 (3-8) 7.5 (6-9.5) 0.35
RAP mean (mmHg) 5 (4-7) 2 (2-3) 0.002
CI (l/min/m2) 1.9 (1.4-2.3) 3.2 (2.5-3.5) 0.002
PAR (dyn*s*cm-5) 1111 (888-1260) 77.9 (32.1-97.6) 0.0004
  1. NT-proBNP N–terminal pro-brain natriuretic peptide, ET-1 endothelin-1, 6MWD six minute walking distance, Hb hemoglobin, PAP mean mean pulmonary arterial pressure, PWP pulmonary wedge pressure, RAP right atrial pressure, CI cardiac index, PAR pulmonary arterial resistance